HRAS - GTPase HRas - human protein (Function)
 
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Gene
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HRAS »  GTPase HRas
 
Protein also known as:  Transforming protein p21. Cleaved into:  GTPase HRas, N-terminally processed.
Gene name:  HRAS
Family name: Small GTPase » Ras
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  
4
  • UniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
2
  • BHF-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
33
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Cell cycle arrestdefinition[GO:0007050]  
2
  • BHF-UCL
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cellular senescencedefinition[GO:0090398]  
1
  • BHF-UCL
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Endocytosisdefinition[GO:0006897] silver  
1
  • Ortholog Compara
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathwaydefinition[GO:0097193] silver  
1
  • Ortholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • BHF-UCL
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • BHF-UCL
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • BHF-UCL
Negative regulation of GTPase activitydefinition[GO:0034260]  
1
  • BHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • BHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • BHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • BHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • BHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • BHF-UCL
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • BHF-UCL
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • BHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • BHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • BHF-UCL
Positive regulation of miRNA metabolic processdefinition[GO:2000630]  
1
  • BHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • BHF-UCL
Positive regulation of Rac protein signal transductiondefinition[GO:0035022] silver  
1
  • Ortholog Compara
Positive regulation of ruffle assemblydefinition[GO:1900029]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
Positive regulation of wound healingdefinition[GO:0090303]  
1
  • BHF-UCL
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Ras protein signal transductiondefinition[GO:0007265]  
1
  • BHF-UCL
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Regulation of synaptic transmission, GABAergicdefinition[GO:0032228] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Social behaviordefinition[GO:0035176] silver  
1
  • Ortholog Compara
Striated muscle cell differentiationdefinition[GO:0051146] silver  
1
  • Ortholog Compara
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Enzymatic activity 
It is regulated in the following manner
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+3265  
Axon guidance  hsa04360+3265  
B cell receptor signaling pathway  hsa04662+3265  
Bladder cancer  hsa05219+3265  
Chemokine signaling pathway  hsa04062+3265  
Cholinergic synapse  hsa04725+3265  
Chronic myeloid leukemia  hsa05220+3265  
Endocytosis  hsa04144+3265  
Endometrial cancer  hsa05213+3265  
ErbB signaling pathway  hsa04012+3265  
Fc epsilon RI signaling pathway  hsa04664+3265  
Focal adhesion  hsa04510+3265  
Gap junction  hsa04540+3265  
Glioma  hsa05214+3265  
GnRH signaling pathway  hsa04912+3265  
Hepatitis C  hsa05160+3265  
HTLV-I infection  hsa05166+3265  
Insulin signaling pathway  hsa04910+3265  
Long-term depression  hsa04730+3265  
Long-term potentiation  hsa04720+3265  
MAPK signaling pathway  hsa04010+3265  
Melanoma  hsa05218+3265  
Natural killer cell mediated cytotoxicity  hsa04650+3265  
Neurotrophin signaling pathway  hsa04722+3265  
Non-small cell lung cancer  hsa05223+3265  
Pathways in cancer  hsa05200+3265  
Prostate cancer  hsa05215+3265  
Regulation of actin cytoskeleton  hsa04810+3265  
Renal cell carcinoma  hsa05211+3265  
T cell receptor signaling pathway  hsa04660+3265  
Thyroid cancer  hsa05216+3265  
Tight junction  hsa04530+3265  
VEGF signaling pathway  hsa04370+3265  
According to Reactome, this protein belongs to the following pathways:
Activation of RAS in B cells  REACT_118778  
Constitutive Signaling by EGFRvIII  REACT_267817  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  REACT_115852  
DAP12 signaling  REACT_147814  
Downstream signal transduction  REACT_17025  
EGFR Transactivation by Gastrin  REACT_121096  
EPHB-mediated forward signaling  REACT_263952  
FCERI mediated MAPK activation  REACT_163701  
FRS2-mediated cascade  REACT_21247  
GRB2 events in EGFR signaling  REACT_12606  
GRB2 events in ERBB2 signaling  REACT_115854  
Interleukin receptor SHC signaling  REACT_23891  
MEK activation  REACT_962  
NCAM signaling for neurite out-growth  REACT_18334  
p38MAPK events  REACT_12065  
RAF activation  REACT_2077  
RAF phosphorylates MEK  REACT_614  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
SHC-mediated cascade  REACT_21374  
SHC-mediated signalling  REACT_661  
SHC1 events in EGFR signaling  REACT_12579  
SHC1 events in ERBB2 signaling  REACT_115993  
SHC1 events in ERBB4 signaling  REACT_116005  
Signaling by FGFR mutants  REACT_121398  
Signaling by SCF-KIT  REACT_111040  
Signalling to RAS  REACT_12033  
SOS-mediated signalling  REACT_524  
Tie2 Signaling  REACT_12621  
VEGFR2 mediated cell proliferation  REACT_264273  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HRAS
GenomeRNAi: 3265
PRO: PR:P01112
Chemistry
GuidetoPHARMACOLOGY: 2822