HRAS - GTPase HRas - human protein (Function)
 
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Protein
Gene
References

 
HRAS »  GTPase HRas
 
Protein also known as:  Transforming protein p21. Cleaved into:  GTPase HRas, N-terminally processed.
Gene name:  HRAS
Family name: Small GTPase » Ras
Entry whose protein(s) existence is based on evidence at protein level
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2 713 2
GENE REF ISO

Function

 show evidences
Overview 
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  
4
  • UniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
2
  • BHF-UCL
  • UniProtKB
GTPase activitydefinition[GO:0003924]  
1
  • WormBase
Protein bindingdefinition[GO:0005515]  
33
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
GO biological process 
Cell cycle arrestdefinition[GO:0007050]  
2
  • BHF-UCL
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cellular senescencedefinition[GO:0090398]  
1
  • BHF-UCL
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Endocytosisdefinition[GO:0006897] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathwaydefinition[GO:0097193] silver  
1
  • Ortholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • BHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • BHF-UCL
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • BHF-UCL
Negative regulation of GTPase activitydefinition[GO:0034260]  
1
  • BHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Positive regulation of actin cytoskeleton reorganizationdefinition[GO:2000251]  
1
  • BHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • BHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • BHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • BHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • BHF-UCL
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • BHF-UCL
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • BHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • BHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • BHF-UCL
Positive regulation of miRNA metabolic processdefinition[GO:2000630]  
1
  • BHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • BHF-UCL
Positive regulation of Ras protein signal transductiondefinition[GO:0046579] silver  
1
  • Ortholog Compara
Positive regulation of ruffle assemblydefinition[GO:1900029]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
Positive regulation of wound healingdefinition[GO:0090303]  
1
  • BHF-UCL
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Ras protein signal transductiondefinition[GO:0007265]  
1
  • BHF-UCL
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Social behaviordefinition[GO:0035176] silver  
1
  • Ortholog Compara
Enzymatic activity 
It is regulated in the following manner
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+3265  
Axon guidance  hsa04360+3265  
B cell receptor signaling pathway  hsa04662+3265  
Bladder cancer  hsa05219+3265  
Chemokine signaling pathway  hsa04062+3265  
Cholinergic synapse  hsa04725+3265  
Chronic myeloid leukemia  hsa05220+3265  
Endocytosis  hsa04144+3265  
Endometrial cancer  hsa05213+3265  
ErbB signaling pathway  hsa04012+3265  
Fc epsilon RI signaling pathway  hsa04664+3265  
Focal adhesion  hsa04510+3265  
Gap junction  hsa04540+3265  
Glioma  hsa05214+3265  
GnRH signaling pathway  hsa04912+3265  
Hepatitis C  hsa05160+3265  
HTLV-I infection  hsa05166+3265  
Insulin signaling pathway  hsa04910+3265  
Long-term depression  hsa04730+3265  
Long-term potentiation  hsa04720+3265  
MAPK signaling pathway  hsa04010+3265  
Melanoma  hsa05218+3265  
Natural killer cell mediated cytotoxicity  hsa04650+3265  
Neurotrophin signaling pathway  hsa04722+3265  
Non-small cell lung cancer  hsa05223+3265  
Pathways in cancer  hsa05200+3265  
Prostate cancer  hsa05215+3265  
Regulation of actin cytoskeleton  hsa04810+3265  
Renal cell carcinoma  hsa05211+3265  
T cell receptor signaling pathway  hsa04660+3265  
Thyroid cancer  hsa05216+3265  
Tight junction  hsa04530+3265  
VEGF signaling pathway  hsa04370+3265  
According to Reactome, this protein belongs to the following pathways:
Activation of RAS in B cells  R-HSA-1169092  
CD209 (DC-SIGN) signaling  R-HSA-5621575  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
DAP12 signaling  R-HSA-2424491  
Downstream signal transduction  R-HSA-186763  
EGFR Transactivation by Gastrin  R-HSA-2179392  
EPHB-mediated forward signaling  R-HSA-3928662  
FCERI mediated MAPK activation  R-HSA-2871796  
FRS-mediated FGFR1 signaling  R-HSA-5654693  
FRS-mediated FGFR2 signaling  R-HSA-5654700  
FRS-mediated FGFR3 signaling  R-HSA-5654706  
FRS-mediated FGFR4 signaling  R-HSA-5654712  
GRB2 events in EGFR signaling  R-HSA-179812  
GRB2 events in ERBB2 signaling  R-HSA-1963640  
Insulin receptor signalling cascade  R-HSA-74751  
MAP2K and MAPK activation  R-HSA-5674135  
NCAM signaling for neurite out-growth  R-HSA-375165  
Negative regulation of MAPK pathway  R-HSA-5675221  
p38MAPK events  R-HSA-171007  
RAF activation  R-HSA-5673000  
RAF/MAP kinase cascade  R-HSA-5673001  
Ras activation uopn Ca2+ infux through NMDA receptor  R-HSA-442982  
Regulation of RAS by GAPs  R-HSA-5658442  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
SHC-related events triggered by IGF1R  R-HSA-2428933  
SHC1 events in EGFR signaling  R-HSA-180336  
SHC1 events in ERBB2 signaling  R-HSA-1250196  
SHC1 events in ERBB4 signaling  R-HSA-1250347  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
Signaling by FGFR4 in disease  R-HSA-5655291  
Signaling by SCF-KIT  R-HSA-1433557  
Signalling to RAS  R-HSA-167044  
SOS-mediated signalling  R-HSA-112412  
Tie2 Signaling  R-HSA-210993  
VEGFR2 mediated cell proliferation  R-HSA-5218921  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HRAS
GenomeRNAi: 3265
PRO: PR:P01112
Chemistry
GuidetoPHARMACOLOGY: 2822