KRAS - GTPase KRas - human protein (Function)
 
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KRAS »  GTPase KRas
 
Protein also known as:  c-Ki-ras. Cleaved into:  GTPase KRas, N-terminally processed.
Gene name:  KRAS
Family name: Small GTPase » Ras
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed23698361, PubMed22711838).  
3
  • UniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003] silver  
1
  • Ortholog Compara
GMP bindingdefinition[GO:0019002] silver  
1
  • Ortholog Compara
GTP bindingdefinition[GO:0005525]  
1
  • UniProtKB KW
LRR domain bindingdefinition[GO:0030275] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Protein complex bindingdefinition[GO:0032403]  
1
  • MGI
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221] silver  
1
  • Ortholog Compara
Endocrine signalingdefinition[GO:0038002] silver  
1
  • Ortholog Compara
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
1
  • Ortholog Compara
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
1
  • Ortholog Compara
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • BHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
1
  • Ortholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
1
  • Ortholog Compara
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • BHF-UCL
Positive regulation of Rac protein signal transductiondefinition[GO:0035022] silver  
1
  • Ortholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Regulation of synaptic transmission, GABAergicdefinition[GO:0032228] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to mineralocorticoiddefinition[GO:0051385] silver  
1
  • Ortholog Compara
Social behaviordefinition[GO:0035176] silver  
1
  • Ortholog Compara
Striated muscle cell differentiationdefinition[GO:0051146] silver  
1
  • Ortholog Compara
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Enzymatic activity 
It is regulated in the following manner
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.  
4
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+3845  
Aldosterone-regulated sodium reabsorption  hsa04960+3845  
Axon guidance  hsa04360+3845  
B cell receptor signaling pathway  hsa04662+3845  
Bladder cancer  hsa05219+3845  
Chemokine signaling pathway  hsa04062+3845  
Cholinergic synapse  hsa04725+3845  
Chronic myeloid leukemia  hsa05220+3845  
Colorectal cancer  hsa05210+3845  
Dorso-ventral axis formation  hsa04320+3845  
Endometrial cancer  hsa05213+3845  
ErbB signaling pathway  hsa04012+3845  
Fc epsilon RI signaling pathway  hsa04664+3845  
Gap junction  hsa04540+3845  
Glioma  hsa05214+3845  
GnRH signaling pathway  hsa04912+3845  
Hepatitis C  hsa05160+3845  
HTLV-I infection  hsa05166+3845  
Insulin signaling pathway  hsa04910+3845  
Long-term depression  hsa04730+3845  
Long-term potentiation  hsa04720+3845  
MAPK signaling pathway  hsa04010+3845  
Melanogenesis  hsa04916+3845  
Melanoma  hsa05218+3845  
Natural killer cell mediated cytotoxicity  hsa04650+3845  
Neurotrophin signaling pathway  hsa04722+3845  
Non-small cell lung cancer  hsa05223+3845  
Pancreatic cancer  hsa05212+3845  
Pathways in cancer  hsa05200+3845  
Progesterone-mediated oocyte maturation  hsa04914+3845  
Prostate cancer  hsa05215+3845  
Regulation of actin cytoskeleton  hsa04810+3845  
Renal cell carcinoma  hsa05211+3845  
T cell receptor signaling pathway  hsa04660+3845  
Thyroid cancer  hsa05216+3845  
Tight junction  hsa04530+3845  
VEGF signaling pathway  hsa04370+3845  
According to Reactome, this protein belongs to the following pathways:
Activation of RAS in B cells  R-HSA-1169092  
CD209 (DC-SIGN) signaling  R-HSA-5621575  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
DAP12 signaling  R-HSA-2424491  
Downstream signal transduction  R-HSA-186763  
EGFR Transactivation by Gastrin  R-HSA-2179392  
FCERI mediated MAPK activation  R-HSA-2871796  
FRS-mediated FGFR1 signaling  R-HSA-5654693  
FRS-mediated FGFR2 signaling  R-HSA-5654700  
FRS-mediated FGFR3 signaling  R-HSA-5654706  
FRS-mediated FGFR4 signaling  R-HSA-5654712  
GRB2 events in EGFR signaling  R-HSA-179812  
GRB2 events in ERBB2 signaling  R-HSA-1963640  
Insulin receptor signalling cascade  R-HSA-74751  
MAP2K and MAPK activation  R-HSA-5674135  
NCAM signaling for neurite out-growth  R-HSA-375165  
Negative regulation of MAPK pathway  R-HSA-5675221  
p38MAPK events  R-HSA-171007  
RAF activation  R-HSA-5673000  
RAF/MAP kinase cascade  R-HSA-5673001  
Regulation of RAS by GAPs  R-HSA-5658442  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
SHC-related events triggered by IGF1R  R-HSA-2428933  
SHC1 events in EGFR signaling  R-HSA-180336  
SHC1 events in ERBB2 signaling  R-HSA-1250196  
SHC1 events in ERBB4 signaling  R-HSA-1250347  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
Signaling by FGFR4 in disease  R-HSA-5655291  
Signaling by SCF-KIT  R-HSA-1433557  
Signalling to RAS  R-HSA-167044  
SOS-mediated signalling  R-HSA-112412  
Tie2 Signaling  R-HSA-210993  
VEGFR2 mediated cell proliferation  R-HSA-5218921  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KRAS
GenomeRNAi: 3845
PRO: PR:P01116
Chemistry
GuidetoPHARMACOLOGY: 2824