KRAS - GTPase KRas - human protein (Function)
 
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KRAS »  GTPase KRas
 
Protein also known as:  c-Ki-ras. Cleaved into:  GTPase KRas, N-terminally processed.
Gene name:  KRAS
Family name: Small GTPase » Ras
Entry whose protein(s) existence is based on evidence at protein level
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1 1717 2
GENE REF ISO

Function

 show evidences
Overview 
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  
  • CuratedUniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003] silver  
  • IEAOrtholog Compara
GMP bindingdefinition[GO:0019002] silver  
  • IEAOrtholog Compara
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
LRR domain bindingdefinition[GO:0030275] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAMGI
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPBHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
  • IEAOrtholog Compara
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IMPBHF-UCL
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to mineralocorticoiddefinition[GO:0051385] silver  
  • IEAOrtholog Compara
Social behaviordefinition[GO:0035176] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+3845  
Aldosterone-regulated sodium reabsorption  hsa04960+3845  
Axon guidance  hsa04360+3845  
B cell receptor signaling pathway  hsa04662+3845  
Bladder cancer  hsa05219+3845  
Chemokine signaling pathway  hsa04062+3845  
Cholinergic synapse  hsa04725+3845  
Chronic myeloid leukemia  hsa05220+3845  
Colorectal cancer  hsa05210+3845  
Dorso-ventral axis formation  hsa04320+3845  
Endometrial cancer  hsa05213+3845  
ErbB signaling pathway  hsa04012+3845  
Fc epsilon RI signaling pathway  hsa04664+3845  
Gap junction  hsa04540+3845  
Glioma  hsa05214+3845  
GnRH signaling pathway  hsa04912+3845  
Hepatitis C  hsa05160+3845  
HTLV-I infection  hsa05166+3845  
Insulin signaling pathway  hsa04910+3845  
Long-term depression  hsa04730+3845  
Long-term potentiation  hsa04720+3845  
MAPK signaling pathway  hsa04010+3845  
Melanogenesis  hsa04916+3845  
Melanoma  hsa05218+3845  
Natural killer cell mediated cytotoxicity  hsa04650+3845  
Neurotrophin signaling pathway  hsa04722+3845  
Non-small cell lung cancer  hsa05223+3845  
Pancreatic cancer  hsa05212+3845  
Pathways in cancer  hsa05200+3845  
Progesterone-mediated oocyte maturation  hsa04914+3845  
Prostate cancer  hsa05215+3845  
Regulation of actin cytoskeleton  hsa04810+3845  
Renal cell carcinoma  hsa05211+3845  
T cell receptor signaling pathway  hsa04660+3845  
Thyroid cancer  hsa05216+3845  
Tight junction  hsa04530+3845  
VEGF signaling pathway  hsa04370+3845  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KRAS
GenomeRNAi: 3845
PRO: PR:P01116