KRAS - GTPase KRas - human protein (Function)
 
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KRAS »  GTPase KRas
 
Protein also known as:  c-Ki-ras. Cleaved into:  GTPase KRas, N-terminally processed.
Gene name:  KRAS
Family name: Small GTPase » Ras
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.  
  • CuratedUniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003] silver  
  • IEAOrtholog Compara
GMP bindingdefinition[GO:0019002] silver  
  • IEAOrtholog Compara
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
LRR domain bindingdefinition[GO:0030275] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403]  
1
  • IDAMGI
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221] silver  
  • IEAOrtholog Compara
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAInterPro 2 GO
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPBHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
  • IEAOrtholog Compara
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IMPBHF-UCL
Positive regulation of Rac protein signal transductiondefinition[GO:0035022] silver  
  • IEAOrtholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmission, GABAergicdefinition[GO:0032228] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to mineralocorticoiddefinition[GO:0051385] silver  
  • IEAOrtholog Compara
Social behaviordefinition[GO:0035176] silver  
  • IEAOrtholog Compara
Striated muscle cell differentiationdefinition[GO:0051146] silver  
  • IEAOrtholog Compara
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+3845  
Aldosterone-regulated sodium reabsorption  hsa04960+3845  
Axon guidance  hsa04360+3845  
B cell receptor signaling pathway  hsa04662+3845  
Bladder cancer  hsa05219+3845  
Chemokine signaling pathway  hsa04062+3845  
Cholinergic synapse  hsa04725+3845  
Chronic myeloid leukemia  hsa05220+3845  
Colorectal cancer  hsa05210+3845  
Dorso-ventral axis formation  hsa04320+3845  
Endometrial cancer  hsa05213+3845  
ErbB signaling pathway  hsa04012+3845  
Fc epsilon RI signaling pathway  hsa04664+3845  
Gap junction  hsa04540+3845  
Glioma  hsa05214+3845  
GnRH signaling pathway  hsa04912+3845  
Hepatitis C  hsa05160+3845  
HTLV-I infection  hsa05166+3845  
Insulin signaling pathway  hsa04910+3845  
Long-term depression  hsa04730+3845  
Long-term potentiation  hsa04720+3845  
MAPK signaling pathway  hsa04010+3845  
Melanogenesis  hsa04916+3845  
Melanoma  hsa05218+3845  
Natural killer cell mediated cytotoxicity  hsa04650+3845  
Neurotrophin signaling pathway  hsa04722+3845  
Non-small cell lung cancer  hsa05223+3845  
Pancreatic cancer  hsa05212+3845  
Pathways in cancer  hsa05200+3845  
Progesterone-mediated oocyte maturation  hsa04914+3845  
Prostate cancer  hsa05215+3845  
Regulation of actin cytoskeleton  hsa04810+3845  
Renal cell carcinoma  hsa05211+3845  
T cell receptor signaling pathway  hsa04660+3845  
Thyroid cancer  hsa05216+3845  
Tight junction  hsa04530+3845  
VEGF signaling pathway  hsa04370+3845  
According to Reactome, this protein belongs to the following pathways:
Activation of RAS in B cells  REACT_118778  
DAP12 signaling  REACT_147814  
Downstream signal transduction  REACT_17025  
EGFR Transactivation by Gastrin  REACT_121096  
FCERI mediated MAPK activation  REACT_163701  
FRS2-mediated cascade  REACT_21247  
GRB2 events in EGFR signaling  REACT_12606  
GRB2 events in ERBB2 signaling  REACT_115854  
MEK activation  REACT_962  
NCAM signaling for neurite out-growth  REACT_18334  
p38MAPK events  REACT_12065  
RAF activation  REACT_2077  
RAF phosphorylates MEK  REACT_614  
SHC-mediated cascade  REACT_21374  
SHC-mediated signalling  REACT_661  
SHC1 events in EGFR signaling  REACT_12579  
SHC1 events in ERBB2 signaling  REACT_115993  
SHC1 events in ERBB4 signaling  REACT_116005  
Signaling by constitutively active EGFR  REACT_115852  
Signaling by FGFR mutants  REACT_121398  
Signaling by SCF-KIT  REACT_111040  
Signalling to RAS  REACT_12033  
SOS-mediated signalling  REACT_524  
Tie2 Signaling  REACT_12621  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KRAS
GenomeRNAi: 3845
PRO: PR:P01116