PDGFB - Platelet-derived growth factor subunit B - human protein (Function)
 
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PDGFB »  Platelet-derived growth factor subunit B  (PDGF subunit B)
 
Protein also known as:  Platelet-derived growth factor beta polypeptide; International Nonproprietary Name Becaplermin.
Gene name:  PDGFB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • IDABHF-UCL
Collagen bindingdefinition[GO:0005518]  
1
  • IDAMGI
Growth factor activitydefinition[GO:0008083]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • IPIBHF-UCL
Contributes to platelet-derived growth factor receptor bindingdefinition[GO:0005161]  
4
  • NASUniProtKB
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Superoxide-generating NADPH oxidase activator activitydefinition[GO:0016176]  
1
  • IDAUniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • IDAUniProtKB
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDAUniProtKB
Blood vessel morphogenesisdefinition[GO:0048514] silver  
  • IEAOrtholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
  • IEAOrtholog Compara
Cell chemotaxisdefinition[GO:0060326]  
3
  • IDABHF-UCL
  • IDAUniProtKB
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell projection assemblydefinition[GO:0030031] silver  
  • IEAOrtholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • IDABHF-UCL
Cellular response to mycophenolic aciddefinition[GO:0071506]  
  • ISSOrtholog Curator
DNA replicationdefinition[GO:0006260] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892]  
  • ISSOrtholog Curator
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Not  Hemopoiesisdefinition[GO:0030097]  
1
  • IMPUniProtKB
Metanephric glomerular endothelium developmentdefinition[GO:0072264] silver  
  • IEAOrtholog Compara
Metanephric glomerular mesangial cell developmentdefinition[GO:0072255]  
  • ISSOrtholog Curator
Metanephric glomerular mesangial cell proliferation involved in metanephros developmentdefinition[GO:0072262] silver  
  • IEAOrtholog Compara
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • IDABHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Negative regulation of phosphatidylinositol biosynthetic processdefinition[GO:0010512]  
1
  • IDABHF-UCL
Negative regulation of platelet activationdefinition[GO:0010544]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Paracrine signalingdefinition[GO:0038001]  
  • ISSOrtholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDAUniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAUniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
4
  • IDABHF-UCL
Positive chemotaxisdefinition[GO:0050918]  
1
  • IDAGOC
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • IDABHF-UCL
Positive regulation of calcium ion importdefinition[GO:0090280]  
1
  • IDAUniProtKB
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell migrationdefinition[GO:0030335]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IDABHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045737]  
1
  • IDAUniProtKB
Positive regulation of DNA biosynthetic processdefinition[GO:2000573]  
7
  • IDAUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
2
  • IDABHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IDABHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
3
  • IDAUniProtKB
Positive regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0045743] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of glomerular filtrationdefinition[GO:0003104]  
  • ISSOrtholog Curator
Positive regulation of glomerular mesangial cell proliferationdefinition[GO:0072126]  
2
  • IDAUniProtKB
Positive regulation of hyaluronan biosynthetic processdefinition[GO:1900127]  
1
  • IDAUniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
4
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IMPUniProtKB
Positive regulation of metanephric mesenchymal cell migrationdefinition[GO:2000591]  
1
  • IDAUniProtKB
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:0035793]  
1
  • IDAUniProtKB
Positive regulation of mitosisdefinition[GO:0045840]  
3
  • IDAUniProtKB
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • IDAUniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
3
  • IDAUniProtKB
Positive regulation of protein autophosphorylationdefinition[GO:0031954]  
2
  • IDAUniProtKB
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • IDAUniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • IDAUniProtKB
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • IMPUniProtKB
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611]  
2
  • NASUniProtKB
  • IDABHF-UCL
Substrate-dependent cell migrationdefinition[GO:0006929] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+5155  
Focal adhesion  hsa04510+5155  
Gap junction  hsa04540+5155  
Glioma  hsa05214+5155  
HTLV-I infection  hsa05166+5155  
MAPK signaling pathway  hsa04010+5155  
Melanoma  hsa05218+5155  
Pathways in cancer  hsa05200+5155  
Prostate cancer  hsa05215+5155  
Regulation of actin cytoskeleton  hsa04810+5155  
Renal cell carcinoma  hsa05211+5155  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Downstream signal transduction  REACT_17025  
Non-integrin membrane-ECM interactions  REACT_163874  
PIP3 activates AKT signaling  REACT_75829  
Signaling by PDGF  REACT_16888  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDGFB
GenomeRNAi: 5155
PRO: PR:P01127