PDGFB - Platelet-derived growth factor subunit B - human protein (Function)
 
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PDGFB »  Platelet-derived growth factor subunit B  (PDGF subunit B)
 
Protein also known as:  Platelet-derived growth factor beta polypeptide; International Nonproprietary Name Becaplermin.
Gene name:  PDGFB
Entry whose protein(s) existence is based on evidence at protein level
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1 208 2
GENE REF ISO

Function

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Overview 
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).  
1
  • UniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056]  
1
  • BHF-UCL
Collagen bindingdefinition[GO:0005518]  
1
  • MGI
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • BHF-UCL
Platelet-derived growth factor receptor bindingdefinition[GO:0005161]  
4
  • UniProtKB
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
Superoxide-generating NADPH oxidase activator activitydefinition[GO:0016176]  
1
  • UniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • UniProtKB
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • UniProtKB
Blood vessel morphogenesisdefinition[GO:0048514] silver  
1
  • Ortholog Compara
Branching involved in salivary gland morphogenesisdefinition[GO:0060445] silver  
1
  • Ortholog Compara
Cell chemotaxisdefinition[GO:0060326]  
3
  • BHF-UCL
  • UniProtKB
Cell growthdefinition[GO:0016049] silver  
1
  • Ortholog Compara
Cell projection assemblydefinition[GO:0030031] silver  
1
  • Ortholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • BHF-UCL
Cellular response to mycophenolic aciddefinition[GO:0071506]  
1
  • Ortholog Curator
DNA replicationdefinition[GO:0006260] silver  
1
  • Ortholog Compara
Embryonic placenta developmentdefinition[GO:0001892]  
1
  • Ortholog Curator
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • Ortholog Curator
Not  Hemopoiesisdefinition[GO:0030097]  
1
  • UniProtKB
Metanephric glomerular endothelium developmentdefinition[GO:0072264] silver  
1
  • Ortholog Compara
Metanephric glomerular mesangial cell developmentdefinition[GO:0072255]  
1
  • Ortholog Curator
Metanephric glomerular mesangial cell proliferation involved in metanephros developmentdefinition[GO:0072262] silver  
1
  • Ortholog Compara
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • BHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336] silver  
1
  • Ortholog Compara
Negative regulation of phosphatidylinositol biosynthetic processdefinition[GO:0010512]  
1
  • BHF-UCL
Negative regulation of platelet activationdefinition[GO:0010544]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Paracrine signalingdefinition[GO:0038001]  
1
  • Ortholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • UniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • UniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
4
  • BHF-UCL
Positive chemotaxisdefinition[GO:0050918]  
1
  • GOC
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • BHF-UCL
Positive regulation of calcium ion importdefinition[GO:0090280]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • BHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921]  
2
  • UniProtKB
  • BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0045737]  
1
  • UniProtKB
Positive regulation of DNA biosynthetic processdefinition[GO:2000573]  
7
  • UniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
2
  • BHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • BHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
3
  • UniProtKB
Positive regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0045743] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
3
  • UniProtKB
  • BHF-UCL
Positive regulation of glomerular filtrationdefinition[GO:0003104]  
1
  • Ortholog Curator
Positive regulation of glomerular mesangial cell proliferationdefinition[GO:0072126]  
2
  • UniProtKB
Positive regulation of hyaluronan biosynthetic processdefinition[GO:1900127]  
1
  • UniProtKB
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
4
  • UniProtKB
  • BHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • UniProtKB
Positive regulation of metanephric mesenchymal cell migrationdefinition[GO:2000591]  
1
  • UniProtKB
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:0035793]  
1
  • UniProtKB
Positive regulation of mitosisdefinition[GO:0045840]  
3
  • UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
3
  • UniProtKB
Positive regulation of protein autophosphorylationdefinition[GO:0031954]  
2
  • UniProtKB
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • UniProtKB
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • UniProtKB
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911]  
2
  • UniProtKB
  • BHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to woundingdefinition[GO:0009611]  
2
  • UniProtKB
  • BHF-UCL
Substrate-dependent cell migrationdefinition[GO:0006929] silver  
1
  • Ortholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+5155  
Focal adhesion  hsa04510+5155  
Gap junction  hsa04540+5155  
Glioma  hsa05214+5155  
HTLV-I infection  hsa05166+5155  
MAPK signaling pathway  hsa04010+5155  
Melanoma  hsa05218+5155  
Pathways in cancer  hsa05200+5155  
Prostate cancer  hsa05215+5155  
Regulation of actin cytoskeleton  hsa04810+5155  
Renal cell carcinoma  hsa05211+5155  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Downstream signal transduction  REACT_17025  
Non-integrin membrane-ECM interactions  REACT_163874  
PIP3 activates AKT signaling  REACT_75829  
Signaling by PDGF  REACT_16888  
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDGFB
GenomeRNAi: 5155
PRO: PR:P01127