LDLR - Low-density lipoprotein receptor - human protein (Function)
 
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LDLR »  Low-density lipoprotein receptor
 
Gene name:  LDLR
Family name: LDLR
Entry whose protein(s) existence is based on evidence at protein level
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1 156 6
GENE REF ISO

Function

 show evidences
Overview 
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIBHF-UCL
Low-density lipoprotein particle bindingdefinition[GO:0030169] silver  
  • IEAOrtholog Compara
Low-density lipoprotein receptor activitydefinition[GO:0005041]  
2
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Very-low-density lipoprotein particle receptor activitydefinition[GO:0030229]  
1
  • IDABHF-UCL
GO biological process 
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IMPBHF-UCL
Cholesterol importdefinition[GO:0070508]  
  • ISSOrtholog Curator
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Cholesterol transportdefinition[GO:0030301]  
1
  • IMPHGNC
Endocytosisdefinition[GO:0006897]  
1
  • TASPINC
Intestinal cholesterol absorptiondefinition[GO:0030299]  
1
  • IMPHGNC
Lipid metabolic processdefinition[GO:0006629]  
2
  • TASPINC
Lipoprotein catabolic processdefinition[GO:0042159] silver  
  • IEAOrtholog Compara
Low-density lipoprotein particle clearancedefinition[GO:0034383]  
1
  • IMPBHF-UCL
Phospholipid transportdefinition[GO:0015914]  
  • ISSOrtholog Curator
Positive regulation of triglyceride biosynthetic processdefinition[GO:0010867]  
  • ISSOrtholog Curator
Regulation of phosphatidylcholine catabolic processdefinition[GO:0010899]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+3949  
Endocytosis  hsa04144+3949  
Hepatitis C  hsa05160+3949  
Toxoplasmosis  hsa05145+3949  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
LDL-mediated lipid transport  REACT_6934  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Endocytosis  definition   [KW-0254]
Host-virus interaction  definition   [KW-0945]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LDL_receptor
GenomeRNAi: 3949
PRO: PR:P01130