TGFB1 - Transforming growth factor beta-1 - human protein (Function)
 
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TGFB1 »  Transforming growth factor beta-1  (TGF-beta-1)
 
Cleaved into:  Latency-associated peptide.
Gene name:  TGFB1
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.  
  • CuratedUniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823]  
1
  • IPIUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
16
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Protein N-terminus bindingdefinition[GO:0047485] silver  
  • IEAOrtholog Compara
Type II transforming growth factor beta receptor bindingdefinition[GO:0005114]  
2
  • IDABHF-UCL
GO biological process 
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsdefinition[GO:0002460] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
ATP biosynthetic processdefinition[GO:0006754]  
1
  • IDABHF-UCL
Branch elongation involved in mammary gland duct branchingdefinition[GO:0060751] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDABHF-UCL
Cell growthdefinition[GO:0016049] silver  
  • IEAInterPro 2 GO
Cell-cell junction organizationdefinition[GO:0045216]  
1
  • IDABHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • IDAUniProtKB
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • IDAUniProtKB
Common-partner SMAD protein phosphorylationdefinition[GO:0007182]  
1
  • IDAUniProtKB
Connective tissue replacement involved in inflammatory response wound healingdefinition[GO:0002248]  
1
  • TASBHF-UCL
Defense response to fungus, incompatible interactiondefinition[GO:0009817] silver  
  • IEAOrtholog Compara
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Embryo developmentdefinition[GO:0009790] silver  
  • IEAOrtholog Compara
Endoderm developmentdefinition[GO:0007492] silver  
  • IEAOrtholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • IDABHF-UCL
Epithelial to mesenchymal transitiondefinition[GO:0001837] silver  
  • IEAOrtholog Compara
Evasion or tolerance of host defenses by virusdefinition[GO:0019049]  
1
  • IDABHF-UCL
Extracellular matrix assemblydefinition[GO:0085029]  
1
  • IDABHF-UCL
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • IDABHF-UCL
Face morphogenesisdefinition[GO:0060325] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Frontal suture morphogenesisdefinition[GO:0060364] silver  
  • IEAOrtholog Compara
Germ cell migrationdefinition[GO:0008354] silver  
  • IEAOrtholog Compara
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • IDAUniProtKB
Hyaluronan catabolic processdefinition[GO:0030214]  
1
  • IDAUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • IDAUniProtKB
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Lens fiber cell differentiationdefinition[GO:0070306] silver  
  • IEAOrtholog Compara
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • IDAUniProtKB
Lymph node developmentdefinition[GO:0048535]  
  • ISSOrtholog Curator
Macrophage derived foam cell differentiationdefinition[GO:0010742]  
1
  • ICBHF-UCL
Mammary gland branching involved in thelarchedefinition[GO:0060744] silver  
  • IEAOrtholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • IMPUniProtKB
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • IDABHF-UCL
Mononuclear cell proliferationdefinition[GO:0032943] silver  
  • IEAOrtholog Compara
Myelinationdefinition[GO:0042552] silver  
  • IEAOrtholog Compara
Myeloid dendritic cell differentiationdefinition[GO:0043011] silver  
  • IEAOrtholog Compara
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IDABHF-UCL
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • IDAHGNC
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDABHF-UCL
Negative regulation of cell-cell adhesiondefinition[GO:0022408]  
1
  • IDABHF-UCL
Negative regulation of DNA replicationdefinition[GO:0008156]  
1
  • IMPBHF-UCL
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
2
  • IMPBHF-UCL
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • IDAUniProtKB
Negative regulation of hyaluronan biosynthetic processdefinition[GO:1900126]  
1
  • IDAUniProtKB
Negative regulation of immune responsedefinition[GO:0050777] silver  
  • IEAOrtholog Compara
Negative regulation of macrophage cytokine productiondefinition[GO:0010936]  
1
  • IDADFLAT
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • IDABHF-UCL
Negative regulation of myoblast differentiationdefinition[GO:0045662]  
1
  • IDAUniProtKB
Negative regulation of neuroblast proliferationdefinition[GO:0007406] silver  
  • IEAOrtholog Compara
Negative regulation of ossificationdefinition[GO:0030279] silver  
  • IEAOrtholog Compara
Negative regulation of phagocytosisdefinition[GO:0050765] silver  
  • IEAOrtholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • IDABHF-UCL
Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280] silver  
  • IEAOrtholog Compara
Negative regulation of skeletal muscle tissue developmentdefinition[GO:0048642]  
1
  • IDAUniProtKB
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • IDAUniProtKB
  • IDAHGNC
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Ossification involved in bone remodelingdefinition[GO:0043932]  
1
  • IEPBHF-UCL
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
3
  • IDABHF-UCL
Phosphate-containing compound metabolic processdefinition[GO:0006796]  
1
  • IDABHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • IDABHF-UCL
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IEPBHF-UCL
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190] silver  
  • IEAOrtholog Compara
Positive regulation of cell cycle arrestdefinition[GO:0071158] silver  
  • IEAOrtholog Compara
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IDAHGNC
  • IDABHF-UCL
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IDABHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • IDABHF-UCL
Positive regulation of collagen biosynthetic processdefinition[GO:0032967]  
2
  • IDABHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
3
  • NASBHF-UCL
Positive regulation of exit from mitosisdefinition[GO:0031536] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast migrationdefinition[GO:0010763]  
1
  • IDABHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Positive regulation of histone acetylationdefinition[GO:0035066] silver  
  • IEAOrtholog Compara
Positive regulation of histone deacetylationdefinition[GO:0031065] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
1
  • IDABHF-UCL
Positive regulation of isotype switching to IgA isotypesdefinition[GO:0048298]  
1
  • IDAMGI
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • IDABHF-UCL
Positive regulation of NAD+ ADP-ribosyltransferase activitydefinition[GO:1901666]  
1
  • IDABHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
  • IEAOrtholog Compara
Positive regulation of odontogenesisdefinition[GO:0042482] silver  
  • IEAOrtholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
2
  • IDABHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
2
  • IDABHF-UCL
Positive regulation of peptidyl-threonine phosphorylationdefinition[GO:0010800]  
2
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • IDABHF-UCL
Positive regulation of protein complex assemblydefinition[GO:0031334]  
1
  • IDABHF-UCL
Positive regulation of protein dephosphorylationdefinition[GO:0035307]  
1
  • IDABHF-UCL
Positive regulation of protein import into nucleusdefinition[GO:0042307]  
1
  • IDABHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDABHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDABHF-UCL
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • IDABHF-UCL
Positive regulation of SMAD protein import into nucleusdefinition[GO:0060391]  
2
  • IDABHF-UCL
Positive regulation of smooth muscle cell differentiationdefinition[GO:0051152] silver  
  • IEAOrtholog Compara
Positive regulation of superoxide anion generationdefinition[GO:0032930]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IDAUniProtKB
  • IDABHF-UCL
  • IDAHGNC
  • ISSOrtholog Curator
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • TASBHF-UCL
Protein export from nucleusdefinition[GO:0006611]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Protein import into nucleus, translocationdefinition[GO:0000060]  
1
  • IDAUniProtKB
Protein kinase B signalingdefinition[GO:0043491]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Receptor catabolic processdefinition[GO:0032801]  
1
  • IDABHF-UCL
Regulation of bindingdefinition[GO:0051098]  
  • ISSOrtholog Curator
Regulation of branching involved in mammary gland duct morphogenesisdefinition[GO:0060762] silver  
  • IEAOrtholog Compara
Regulation of cartilage developmentdefinition[GO:0061035] silver  
  • IEAOrtholog Compara
Regulation of cell migrationdefinition[GO:0030334]  
1
  • TASBHF-UCL
Regulation of DNA bindingdefinition[GO:0051101]  
  • ISSOrtholog Curator
Regulation of protein import into nucleusdefinition[GO:0042306]  
  • ISSOrtholog Curator
Regulation of sodium ion transportdefinition[GO:0002028] silver  
  • IEAOrtholog Compara
Regulation of striated muscle tissue developmentdefinition[GO:0016202]  
  • ISSOrtholog Curator
Regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0017015]  
1
  • IDABHF-UCL
Regulatory T cell differentiationdefinition[GO:0045066] silver  
  • IEAOrtholog Compara
Response to cholesteroldefinition[GO:0070723]  
1
  • IDABHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355]  
1
  • IDABHF-UCL
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to laminar fluid shear stressdefinition[GO:0034616] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570]  
1
  • IDABHF-UCL
Response to radiationdefinition[GO:0009314] silver  
  • IEAOrtholog Compara
Response to vitamin Ddefinition[GO:0033280] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611]  
1
  • IEPBHF-UCL
Salivary gland morphogenesisdefinition[GO:0007435]  
1
  • IEPBHF-UCL
SMAD protein complex assemblydefinition[GO:0007183]  
1
  • IDABHF-UCL
SMAD protein import into nucleusdefinition[GO:0007184]  
1
  • IDABHF-UCL
T cell homeostasisdefinition[GO:0043029] silver  
  • IEAOrtholog Compara
Tolerance induction to self antigendefinition[GO:0002513] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]