TGFB1 - Transforming growth factor beta-1 - human protein (Function)
 
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TGFB1 »  Transforming growth factor beta-1  (TGF-beta-1)
 
Cleaved into:  Latency-associated peptide.
Gene name:  TGFB1
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.  
1
  • UniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823]  
1
  • UniProtKB
Cytokine activitydefinition[GO:0005125]  
1
  • AgBase
Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
Glycoprotein bindingdefinition[GO:0001948]  
1
  • UniProtKB
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
17
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Protein N-terminus bindingdefinition[GO:0047485] silver  
1
  • Ortholog Compara
Type II transforming growth factor beta receptor bindingdefinition[GO:0005114]  
2
  • BHF-UCL
GO biological process 
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsdefinition[GO:0002460] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
ATP biosynthetic processdefinition[GO:0006754]  
1
  • BHF-UCL
Branch elongation involved in mammary gland duct branchingdefinition[GO:0060751] silver  
1
  • Ortholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • BHF-UCL
Cell growthdefinition[GO:0016049] silver  
1
  • InterPro 2 GO
Cell-cell junction organizationdefinition[GO:0045216]  
1
  • BHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • UniProtKB
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • BHF-UCL
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • UniProtKB
Common-partner SMAD protein phosphorylationdefinition[GO:0007182]  
1
  • UniProtKB
Connective tissue replacement involved in inflammatory response wound healingdefinition[GO:0002248]  
1
  • BHF-UCL
Defense response to fungus, incompatible interactiondefinition[GO:0009817] silver  
1
  • Ortholog Compara
Digestive tract developmentdefinition[GO:0048565] silver  
1
  • Ortholog Compara
Endoderm developmentdefinition[GO:0007492] silver  
1
  • Ortholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • BHF-UCL
Epithelial to mesenchymal transitiondefinition[GO:0001837] silver  
1
  • Ortholog Compara
Evasion or tolerance of host defenses by virusdefinition[GO:0019049]  
1
  • BHF-UCL
Extracellular matrix assemblydefinition[GO:0085029]  
1
  • BHF-UCL
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • BHF-UCL
Face morphogenesisdefinition[GO:0060325] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Frontal suture morphogenesisdefinition[GO:0060364] silver  
1
  • Ortholog Compara
Germ cell migrationdefinition[GO:0008354] silver  
1
  • Ortholog Compara
Hematopoietic progenitor cell differentiationdefinition[GO:0002244]  
1
  • UniProtKB
Hyaluronan catabolic processdefinition[GO:0030214]  
1
  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB
Inner ear developmentdefinition[GO:0048839] silver  
1
  • Ortholog Compara
Lens fiber cell differentiationdefinition[GO:0070306] silver  
1
  • Ortholog Compara
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • UniProtKB
Lymph node developmentdefinition[GO:0048535]  
1
  • Ortholog Curator
Macrophage derived foam cell differentiationdefinition[GO:0010742]  
1
  • BHF-UCL
Mammary gland branching involved in thelarchedefinition[GO:0060744] silver  
1
  • Ortholog Compara
MAPK cascadedefinition[GO:0000165]  
1
  • UniProtKB
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • BHF-UCL
Mononuclear cell proliferationdefinition[GO:0032943] silver  
1
  • Ortholog Compara
Myelinationdefinition[GO:0042552] silver  
1
  • Ortholog Compara
Myeloid dendritic cell differentiationdefinition[GO:0043011] silver  
1
  • Ortholog Compara
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • BHF-UCL
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • HGNC
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • BHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • BHF-UCL
Negative regulation of cell-cell adhesiondefinition[GO:0022408]  
1
  • BHF-UCL
Negative regulation of DNA replicationdefinition[GO:0008156]  
1
  • BHF-UCL
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
2
  • BHF-UCL
Negative regulation of extracellular matrix disassemblydefinition[GO:0010716]  
1
  • BHF-UCL
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • UniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • BHF-UCL
Negative regulation of hyaluronan biosynthetic processdefinition[GO:1900126]  
1
  • UniProtKB
Negative regulation of macrophage cytokine productiondefinition[GO:0010936]  
1
  • DFLAT
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • BHF-UCL
Negative regulation of myoblast differentiationdefinition[GO:0045662]  
1
  • UniProtKB
Negative regulation of neuroblast proliferationdefinition[GO:0007406] silver  
1
  • Ortholog Compara
Negative regulation of ossificationdefinition[GO:0030279] silver  
1
  • Ortholog Compara
Negative regulation of phagocytosisdefinition[GO:0050765] silver  
1
  • Ortholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • BHF-UCL
Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280] silver  
1
  • Ortholog Compara
Negative regulation of skeletal muscle tissue developmentdefinition[GO:0048642]  
1
  • UniProtKB
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • UniProtKB
  • HGNC
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Ossification involved in bone remodelingdefinition[GO:0043932]  
1
  • BHF-UCL
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
3
  • BHF-UCL
Phosphate-containing compound metabolic processdefinition[GO:0006796]  
1
  • BHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • BHF-UCL
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • BHF-UCL
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190] silver  
1
  • Ortholog Compara
Positive regulation of cell cycle arrestdefinition[GO:0071158] silver  
1
  • Ortholog Compara
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • BHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • HGNC
  • BHF-UCL
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • BHF-UCL
Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • BHF-UCL
Positive regulation of collagen biosynthetic processdefinition[GO:0032967]  
3
  • BHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
1
  • Ortholog Compara
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
3
  • BHF-UCL
Positive regulation of exit from mitosisdefinition[GO:0031536] silver  
1
  • Ortholog Compara
Positive regulation of extracellular matrix assemblydefinition[GO:1901203]  
1
  • BHF-UCL
Positive regulation of fibroblast migrationdefinition[GO:0010763]  
1
  • BHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
3
  • BHF-UCL
  • UniProtKB
Positive regulation of histone acetylationdefinition[GO:0035066] silver  
1
  • Ortholog Compara
Positive regulation of histone deacetylationdefinition[GO:0031065] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
1
  • BHF-UCL
Positive regulation of isotype switching to IgA isotypesdefinition[GO:0048298]  
1
  • MGI
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • BHF-UCL
Positive regulation of NAD+ ADP-ribosyltransferase activitydefinition[GO:1901666]  
1
  • BHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
1
  • Ortholog Compara
Positive regulation of odontogenesisdefinition[GO:0042482] silver  
1
  • Ortholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
2
  • BHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
2
  • BHF-UCL
Positive regulation of peptidyl-threonine phosphorylationdefinition[GO:0010800]  
2
  • BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • BHF-UCL
Positive regulation of protein complex assemblydefinition[GO:0031334]  
1
  • BHF-UCL
Positive regulation of protein dephosphorylationdefinition[GO:0035307]  
1
  • BHF-UCL
Positive regulation of protein import into nucleusdefinition[GO:0042307]  
1
  • BHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • BHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • BHF-UCL
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • BHF-UCL
Positive regulation of SMAD protein import into nucleusdefinition[GO:0060391]  
2
  • BHF-UCL
Positive regulation of smooth muscle cell differentiationdefinition[GO:0051152] silver  
1
  • Ortholog Compara
Positive regulation of superoxide anion generationdefinition[GO:0032930]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
5
  • UniProtKB
  • BHF-UCL
  • HGNC
  • Ortholog Curator
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • BHF-UCL
Protein export from nucleusdefinition[GO:0006611]  
3
  • UniProtKB
  • BHF-UCL
Protein import into nucleus, translocationdefinition[GO:0000060]  
1
  • UniProtKB
Protein kinase B signalingdefinition[GO:0043491]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • Ortholog Curator
Receptor catabolic process