NGF - Beta-nerve growth factor - human protein (Function)
 
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NGF »  Beta-nerve growth factor  (Beta-NGF)
 
Gene name:  NGF
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed20164177).  
2
  • UniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • RefGenome
Metalloendopeptidase inhibitor activitydefinition[GO:0008191]  
1
  • UniProtKB
Nerve growth factor receptor bindingdefinition[GO:0005163]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Receptor signaling protein activitydefinition[GO:0005057] silver  
1
  • Ortholog Compara
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • RefGenome
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • BHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
2
  • GOC
  • UniProtKB KW
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • RefGenome
Negative regulation of type B pancreatic cell apoptotic processdefinition[GO:2000675] silver  
1
  • Ortholog Compara
Nerve growth factor signaling pathwaydefinition[GO:0038180] silver  
1
  • Ortholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • MGI
Peripheral nervous system developmentdefinition[GO:0007422] silver  
1
  • Ortholog Compara
Positive regulation of axon extensiondefinition[GO:0045773] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of neuron maturationdefinition[GO:0014042] silver  
1
  • Ortholog Compara
Positive regulation of neurotrophin TRK receptor signaling pathwaydefinition[GO:0051388] silver  
1
  • Ortholog Compara
Positive regulation of protein autophosphorylationdefinition[GO:0031954] silver  
1
  • Ortholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091] silver  
1
  • Ortholog Compara
Positive regulation of stem cell proliferationdefinition[GO:2000648] silver  
1
  • Ortholog Compara
Regulation of neuron differentiationdefinition[GO:0045664]  
1
  • RefGenome
Regulation of neurotransmitter secretiondefinition[GO:0046928] silver  
1
  • Ortholog Compara
Regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051279] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Response to nicotinedefinition[GO:0035094] silver  
1
  • Ortholog Compara
Response to ozonedefinition[GO:0010193] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Response to radiationdefinition[GO:0009314] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+4803  
MAPK signaling pathway  hsa04010+4803  
Neurotrophin signaling pathway  hsa04722+4803  
According to Reactome, this protein belongs to the following pathways:
ARMS-mediated activation  REACT_12002  
Axonal growth stimulation  REACT_13779  
Ceramide signalling  REACT_13806  
Frs2-mediated activation  REACT_12076  
NADE modulates death signalling  REACT_13526  
NF-kB is activated and signals survival  REACT_13696  
NFG and proNGF binds to p75NTR  REACT_13724  
NGF processing  REACT_11062  
NRAGE signals death through JNK  REACT_13638  
NRIF signals cell death from the nucleus  REACT_13643  
p75NTR negatively regulates cell cycle via SC1  REACT_13695  
p75NTR recruits signalling complexes  REACT_13415  
PI3K/AKT activation  REACT_12464  
PLC-gamma1 signalling  REACT_12079  
Retrograde neurotrophin signalling  REACT_12435  
Signalling to p38 via RIT and RIN  REACT_12077  
Signalling to RAS  REACT_12033  
Signalling to STAT3  REACT_12049  
TRKA activation by NGF  REACT_11060  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Metalloenzyme inhibitor  definition   [KW-0481]
Metalloprotease inhibitor  definition   [KW-0483]
Protease inhibitor  definition   [KW-0646]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Nerve_growth_factor
GenomeRNAi: 4803
PRO: PR:P01138