NGF - Beta-nerve growth factor - human protein (Function)
 
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NGF »  Beta-nerve growth factor  (Beta-NGF)
 
Gene name:  NGF
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed20164177).  
2
  • UniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • RefGenome
Metalloendopeptidase inhibitor activitydefinition[GO:0008191]  
1
  • UniProtKB
Nerve growth factor receptor bindingdefinition[GO:0005163]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Receptor signaling protein activitydefinition[GO:0005057] silver  
1
  • Ortholog Compara
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • RefGenome
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • BHF-UCL
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
2
  • GOC
  • UniProtKB KW
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • RefGenome
Nerve growth factor signaling pathwaydefinition[GO:0038180] silver  
1
  • Ortholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • MGI
Peripheral nervous system developmentdefinition[GO:0007422] silver  
1
  • Ortholog Compara
Positive regulation of axon extensiondefinition[GO:0045773] silver  
1
  • Ortholog Compara
Positive regulation of collateral sproutingdefinition[GO:0048672] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of neuron maturationdefinition[GO:0014042] silver  
1
  • Ortholog Compara
Regulation of neuron differentiationdefinition[GO:0045664]  
1
  • RefGenome
Regulation of neurotransmitter secretiondefinition[GO:0046928] silver  
1
  • Ortholog Compara
Regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051279] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+4803  
MAPK signaling pathway  hsa04010+4803  
Neurotrophin signaling pathway  hsa04722+4803  
According to Reactome, this protein belongs to the following pathways:
ARMS-mediated activation  R-HSA-170984  
Axonal growth stimulation  R-HSA-209563  
Ceramide signalling  R-HSA-193681  
Frs2-mediated activation  R-HSA-170968  
NADE modulates death signalling  R-HSA-205025  
NF-kB is activated and signals survival  R-HSA-209560  
NFG and proNGF binds to p75NTR  R-HSA-205017  
NGF processing  R-HSA-167060  
NRAGE signals death through JNK  R-HSA-193648  
NRIF signals cell death from the nucleus  R-HSA-205043  
p75NTR negatively regulates cell cycle via SC1  R-HSA-193670  
p75NTR recruits signalling complexes  R-HSA-209543  
PI3K/AKT activation  R-HSA-198203  
PLC-gamma1 signalling  R-HSA-167021  
Retrograde neurotrophin signalling  R-HSA-177504  
Signalling to p38 via RIT and RIN  R-HSA-187706  
Signalling to RAS  R-HSA-167044  
Signalling to STAT3  R-HSA-198745  
TRKA activation by NGF  R-HSA-187042  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Metalloenzyme inhibitor  definition   [KW-0481]
Metalloprotease inhibitor  definition   [KW-0483]
Protease inhibitor  definition   [KW-0646]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Nerve_growth_factor
GenomeRNAi: 4803
PRO: PR:P01138