NGF - Beta-nerve growth factor - human protein (Function)
 
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NGF »  Beta-nerve growth factor  (Beta-NGF)
 
Gene name:  NGF
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.  
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Nerve growth factor receptor bindingdefinition[GO:0005163]  
1
  • IPIBHF-UCL
Receptor signaling protein activitydefinition[GO:0005057] silver  
  • IEAOrtholog Compara
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • IDABHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of type B pancreatic cell apoptotic processdefinition[GO:2000675] silver  
  • IEAOrtholog Compara
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • IDAMGI
Peripheral nervous system developmentdefinition[GO:0007422] silver  
  • IEAOrtholog Compara
Positive regulation of axon extensiondefinition[GO:0045773] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPUniProtKB
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of neurotrophin TRK receptor signaling pathwaydefinition[GO:0051388] silver  
  • IEAOrtholog Compara
Positive regulation of protein autophosphorylationdefinition[GO:0031954] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091] silver  
  • IEAOrtholog Compara
Positive regulation of stem cell proliferationdefinition[GO:2000648] silver  
  • IEAOrtholog Compara
Regulation of neurotransmitter secretiondefinition[GO:0046928] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Response to ozonedefinition[GO:0010193] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Response to radiationdefinition[GO:0009314] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+4803  
MAPK signaling pathway  hsa04010+4803  
Neurotrophin signaling pathway  hsa04722+4803  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Nerve_growth_factor
GenomeRNAi: 4803
PRO: PR:P01138