NPPA - Natriuretic peptides A - human protein (Function)
 
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NPPA »  Natriuretic peptides A
 
Protein also known as:  Prepronatriodilatin. Cleaved into:  Atrial natriuretic factor; Cardiodilatin-related peptide.
Gene name:  NPPA
Family name: Natriuretic peptide
Entry whose protein(s) existence is based on evidence at protein level
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1 137 1
GENE REF ISO

Function

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Overview 
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.  
1
  • CuratedUniProtKB
GO molecular function 
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Peptide hormone receptor bindingdefinition[GO:0051428] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
2
  • IPIUniProtKB
GO biological process 
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • IDAUniProtKB
Female pregnancydefinition[GO:0007565]  
  • ISSOrtholog Curator
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of systemic arterial blood pressuredefinition[GO:0003085] silver  
  • IEAOrtholog Compara
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168]  
1
  • IDAUniProtKB
Regulation of blood pressuredefinition[GO:0008217]  
2
  • IDAUniProtKB
Regulation of blood vessel sizedefinition[GO:0050880]  
  • IEAUniProtKB KW
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Amyloids  REACT_75925  
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Vasoactive  definition   [KW-0838]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Atrial_natriuretic_peptide
GenomeRNAi: 4878
PRO: PR:P01160