PRL - Prolactin - human protein (Function)
 
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Protein
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PRL »  Prolactin  (PRL)
 
Gene name:  PRL
Family name: Somatotropin/prolactin
Entry whose protein(s) existence is based on evidence at protein level
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1 179 1
GENE REF ISO

Function

 show evidences
Overview 
Prolactin acts primarily on the mammary gland by promoting lactation.  
  • CuratedUniProtKB
GO molecular function 
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Prolactin receptor bindingdefinition[GO:0005148]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Female pregnancydefinition[GO:0007565]  
1
  • NASPINC
Lactationdefinition[GO:0007595]  
  • IEAUniProtKB KW
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
1
  • IDABHF-UCL
Regulation of multicellular organism growthdefinition[GO:0040014]  
1
  • IEPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+5617  
Jak-STAT signaling pathway  hsa04630+5617  
Neuroactive ligand-receptor interaction  hsa04080+5617  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Lactation  definition   [KW-0421]
Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Prolactin
GenomeRNAi: 5617
PRO: PR:P01236