GH1 - Somatotropin - human protein (Function)
 
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Protein
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GH1 »  Somatotropin
 
Protein also known as:  Pituitary growth hormone.
Gene name:  GH1
Family name: Somatotropin/prolactin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.  
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • IPIBHF-UCL
Growth hormone receptor bindingdefinition[GO:0005131]  
3
  • IPIBHF-UCL
  • IDAMGI
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Prolactin receptor bindingdefinition[GO:0005148]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Bone maturationdefinition[GO:0070977]  
1
  • IDABHF-UCL
Glucose transportdefinition[GO:0015758]  
1
  • IDAMGI
Growth hormone receptor signaling pathwaydefinition[GO:0060396]  
1
  • IDABHF-UCL
JAK-STAT cascadedefinition[GO:0007259]  
1
  • IDABHF-UCL
Positive regulation of activation of JAK2 kinase activitydefinition[GO:0010535]  
2
  • IDABHF-UCL
Positive regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043568]  
1
  • IDABHF-UCL
Positive regulation of JAK-STAT cascadedefinition[GO:0046427]  
1
  • IDABHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • TASBHF-UCL
Positive regulation of multicellular organism growthdefinition[GO:0040018]  
3
  • IDABHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IDABHF-UCL
Not  Positive regulation of receptor internalizationdefinition[GO:0002092]  
1
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
2
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
2
  • IDABHF-UCL
Response to estradioldefinition[GO:0032355]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+2688  
Jak-STAT signaling pathway  hsa04630+2688  
Neuroactive ligand-receptor interaction  hsa04080+2688  
According to Reactome, this protein belongs to the following pathways:
Growth hormone receptor signaling  REACT_111133  
Prolactin receptor signaling  REACT_115697  
Synthesis, secretion, and deacylation of Ghrelin  REACT_19189  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2688
PRO: PR:P01241