INS - Insulin - human protein (Function)
 
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INS »  Insulin
 
Cleaved into:  Insulin A chain; Insulin B chain.
Gene name:  INS
Family name: Insulin
Entry whose protein(s) existence is based on evidence at protein level
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1 553 1
GENE REF ISO

Function

 show evidences
Overview 
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.  
  • CuratedUniProtKB
GO molecular function 
Hormone activitydefinition[GO:0005179]  
3
  • NASUniProtKB
  • ICBHF-UCL
Identical protein bindingdefinition[GO:0042802]  
4
  • IPIIntAct
Insulin receptor bindingdefinition[GO:0005158]  
3
  • IDABHF-UCL
  • IDAUniProtKB
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • IPIBHF-UCL
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
GO biological process 
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDABHF-UCL
Acute-phase responsedefinition[GO:0006953]  
1
  • IDABHF-UCL
Alpha-beta T cell activationdefinition[GO:0046631]  
1
  • IDAUniProtKB
Cell-cell signalingdefinition[GO:0007267]  
1
  • ICUniProtKB
Fatty acid homeostasisdefinition[GO:0055089]  
1
  • IMPBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Glucose homeostasisdefinition[GO:0042593]  
1
  • IMPBHF-UCL
Glucose metabolic processdefinition[GO:0006006]  
  • IEAUniProtKB KW
Glucose transportdefinition[GO:0015758]  
2
  • IDAUniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • IDABHF-UCL
Negative regulation of acute inflammatory responsedefinition[GO:0002674]  
1
  • IDABHF-UCL
Negative regulation of fatty acid metabolic processdefinition[GO:0045922]  
1
  • IMPBHF-UCL
Negative regulation of feeding behaviordefinition[GO:2000252]  
1
  • IDADFLAT
Negative regulation of gluconeogenesisdefinition[GO:0045721]  
1
  • NASBHF-UCL
Negative regulation of glycogen catabolic processdefinition[GO:0045818]  
1
  • IMPBHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • NASBHF-UCL
Negative regulation of NAD(P)H oxidase activitydefinition[GO:0033861]  
1
  • IDABHF-UCL
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902176]  
1
  • NASBHF-UCL
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IDAUniProtKB
Negative regulation of protein oligomerizationdefinition[GO:0032460]  
1
  • IDAUniProtKB
Negative regulation of protein secretiondefinition[GO:0050709]  
1
  • IDABHF-UCL
Negative regulation of proteolysisdefinition[GO:0045861]  
1
  • IMPBHF-UCL
Negative regulation of respiratory burst involved in inflammatory responsedefinition[GO:0060266]  
1
  • IDABHF-UCL
Negative regulation of vasodilationdefinition[GO:0045908]  
1
  • NASUniProtKB
Positive regulation of brown fat cell differentiationdefinition[GO:0090336]  
1
  • TASBHF-UCL
Positive regulation of cell differentiationdefinition[GO:0045597]  
1
  • NASBHF-UCL
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • NASBHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • ISSBHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IMPBHF-UCL
Positive regulation of cytokine secretiondefinition[GO:0050715]  
1
  • IDAUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • IDABHF-UCL
Positive regulation of glucose importdefinition[GO:0046326]  
1
  • IDABHF-UCL
Positive regulation of glycogen biosynthetic processdefinition[GO:0045725]  
1
  • IDABHF-UCL
Positive regulation of glycolytic processdefinition[GO:0045821]  
2
  • IDABHF-UCL
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628]  
1
  • IDABHF-UCL
Positive regulation of lipid biosynthetic processdefinition[GO:0046889]  
1
  • NASBHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDABHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDABHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • NASUniProtKB
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • NASUniProtKB
Positive regulation of peptide hormone secretiondefinition[GO:0090277]  
1
  • TASBHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IDABHF-UCL
Positive regulation of protein autophosphorylationdefinition[GO:0031954]  
1
  • ISSBHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDABHF-UCL
Positive regulation of respiratory burstdefinition[GO:0060267]  
1
  • IDABHF-UCL
Positive regulation of vasodilationdefinition[GO:0045909]  
1
  • NASUniProtKB
Regulation of cellular amino acid metabolic processdefinition[GO:0006521]  
1
  • IMPBHF-UCL
Regulation of protein localizationdefinition[GO:0032880]  
1
  • IDABHF-UCL
Regulation of protein secretiondefinition[GO:0050708]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASBHF-UCL
Regulation of transmembrane transporter activitydefinition[GO:0022898]  
1
  • IDABHF-UCL
Wound healingdefinition[GO:0042060]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+3630  
Insulin signaling pathway  hsa04910+3630  
Maturity onset diabetes of the young  hsa04950+3630  
mTOR signaling pathway  hsa04150+3630  
Oocyte meiosis  hsa04114+3630  
Progesterone-mediated oocyte maturation  hsa04914+3630  
Prostate cancer  hsa05215+3630  
Regulation of actin cytoskeleton  hsa04810+3630  
Regulation of autophagy  hsa04140+3630  
Type I diabetes mellitus  hsa04940+3630  
Type II diabetes mellitus  hsa04930+3630  
According to Reactome, this protein belongs to the following pathways:
Insulin processing  REACT_15550  
Insulin receptor recycling  REACT_1109  
IRS activation  REACT_570  
Regulation of gene expression in beta cells  REACT_13819  
Regulation of insulin secretion  REACT_18325  
SHC activation  REACT_1661  
Signal attenuation  REACT_508  
Signaling by Insulin receptor  REACT_498  
Synthesis, secretion, and deacylation of Ghrelin  REACT_19189  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Insulin
GenomeRNAi: 3630
PRO: PR:P01308