IGF2 - Insulin-like growth factor II - human protein (Function)
 
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IGF2 »  Insulin-like growth factor II  (IGF-II)
 
Protein also known as:  Somatomedin-A. Cleaved into:  Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin.
Gene name:  IGF2
Family name: Insulin
Entry whose protein(s) existence is based on evidence at protein level
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1 376 3
GENE REF ISO

Function

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Overview 
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.  
1
  • CuratedUniProtKB
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.  
1
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • IDABHF-UCL
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Insulin receptor bindingdefinition[GO:0005158]  
1
  • IPIBHF-UCL
Insulin-like growth factor receptor bindingdefinition[GO:0005159] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein serine/threonine kinase activator activitydefinition[GO:0043539]  
  • ISSOrtholog Curator
Receptor activator activitydefinition[GO:0030546]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Exocrine pancreas developmentdefinition[GO:0031017] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Glucose metabolic processdefinition[GO:0006006]  
  • IEAUniProtKB KW
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • TASPINC
Insulin receptor signaling pathway via phosphatidylinositol 3-kinasedefinition[GO:0038028]  
  • ISSOrtholog Curator
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • IDABHF-UCL
Positive regulation of catalytic activitydefinition[GO:0043085]  
  • ISSOrtholog Curator
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • ICBHF-UCL
Positive regulation of glycogen (starch) synthase activitydefinition[GO:2000467]  
  • ISSOrtholog Curator
Positive regulation of glycogen biosynthetic processdefinition[GO:0045725]  
  • ISSOrtholog Curator
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628]  
1
  • IDABHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDABHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • IDABHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
  • ISSOrtholog Curator
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IDABHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
  • ISSOrtholog Curator
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902] silver  
  • IEAOrtholog Compara
Positive regulation of receptor activitydefinition[GO:2000273] silver  
  • IEAOrtholog Compara
Positive regulation of steroid hormone biosynthetic processdefinition[GO:0090031] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of gene expression by genetic imprintingdefinition[GO:0006349]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASBHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Response to radiationdefinition[GO:0009314] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Striated muscle cell differentiationdefinition[GO:0051146] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
IRS-related events triggered by IGF1R  REACT_150203  
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)  REACT_15428  
SHC-related events triggered by IGF1R  REACT_150139  
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)  REACT_150359  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Osteogenesis  definition   [KW-0892]
Molecular function 
Growth factor  definition   [KW-0339]
Hormone  definition   [KW-0372]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links