TNF - Tumor necrosis factor - human protein (Medical)
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TNF »  Tumor necrosis factor
Protein also known as:  Tumor necrosis factor ligand superfamily member 2 (TNF-a). Cleaved into:  C-domain 1; C-domain 2; Intracellular domain 1; Intracellular domain 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form.
Gene name:  TNF
Family name: Tumor necrosis factor
Entry whose protein(s) existence is based on evidence at protein level
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7 2867 1

Displayed isoform: Iso 1



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Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Disease susceptibility is associated with variations affecting the gene represented in this entry.  
  • UniProtKB
According to Orphanet, this protein is involved in the following disease:
Adult psoriatic arthritis  40050  
Genetic variations in TNF influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].  
  • UniProtKB
Genetic variations in TNF are involved in susceptibility to malaria [MIM:611162].  
  • UniProtKB
According to DrugBank, this protein binds/interacts with the following drugs:
Adalimumab  DB00051  
Amrinone  DB01427  
Certolizumab pegol  DB08904  
Chloroquine  DB00608  
Clenbuterol  DB01407  
Epinephrine  DB00668  
Etanercept  DB00005  
Glucosamine  DB01296  
golimumab  DB06674  
Infliximab  DB00065  
Pomalidomide  DB08910  
Pranlukast  DB01411  
Pseudoephedrine  DB00852  
Thalidomide  DB01041  


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 7124
MalaCards: TNF
MIM: 610424 [ phenotype ]
MIM: 611162 [ phenotype ]
MIM: 607507
PharmGKB: PA435
Polymorphism and mutation databases
BioMuta: TNF
DMDM: 135934
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.