IL1B - Interleukin-1 beta - human protein (Function)
 
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IL1B »  Interleukin-1 beta  (IL-1 beta)
 
Protein also known as:  Catabolin.
Gene name:  IL1B
Family name: IL-1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.  
2
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
2
  • BHF-UCL
Interleukin-1 receptor bindingdefinition[GO:0005149]  
1
  • UniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • BHF-UCL
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • PINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cellular response to antibioticdefinition[GO:0071236] silver  
1
  • Ortholog Compara
Cellular response to drugdefinition[GO:0035690]  
1
  • MGI
Cellular response to fatty aciddefinition[GO:0071398] silver  
1
  • Ortholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Cellular response to methotrexatedefinition[GO:0071414] silver  
1
  • Ortholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • UniProtKB
Cellular response to organic substancedefinition[GO:0071310]  
1
  • MGI
Chronic inflammatory response to antigenic stimulusdefinition[GO:0002439] silver  
1
  • Ortholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • BHF-UCL
Ectopic germ cell programmed cell deathdefinition[GO:0035234] silver  
1
  • Ortholog Compara
Embryo implantationdefinition[GO:0007566]  
1
  • BHF-UCL
Estrogen metabolic processdefinition[GO:0008210] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
1
  • Ortholog Compara
Fever generationdefinition[GO:0001660] silver  
1
  • Ortholog Compara
Glycoprotein metabolic processdefinition[GO:0009100] silver  
1
  • Ortholog Compara
Hyaluronan biosynthetic processdefinition[GO:0030213]  
1
  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
3
  • UniProtKB
  • BHF-UCL
Interleukin-1 beta productiondefinition[GO:0032611] silver  
1
  • Ortholog Compara
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • UniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • UniProtKB
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Monocyte aggregationdefinition[GO:0070487]  
1
  • UniProtKB
Negative regulation of adiponectin secretiondefinition[GO:0070164]  
1
  • BHF-UCL
Negative regulation of branching morphogenesis of a nervedefinition[GO:2000173] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • BHF-UCL
Negative regulation of glucose transportdefinition[GO:0010829]  
1
  • BHF-UCL
Negative regulation of glutamate secretiondefinition[GO:0014050] silver  
1
  • Ortholog Compara
Negative regulation of insulin receptor signaling pathwaydefinition[GO:0046627]  
1
  • BHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • BHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • BHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • BHF-UCL
Negative regulation of neural precursor cell proliferationdefinition[GO:2000178] silver  
1
  • Ortholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Neutrophil chemotaxisdefinition[GO:0030593] silver  
1
  • Ortholog Compara
Ovulationdefinition[GO:0030728] silver  
1
  • Ortholog Compara
Pentacyclic triterpenoid metabolic processdefinition[GO:0019742] silver  
1
  • Ortholog Compara
Polyketide metabolic processdefinition[GO:0030638] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • Ortholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of astrocyte differentiationdefinition[GO:0048711] silver  
1
  • Ortholog Compara
Positive regulation of calcidiol 1-monooxygenase activitydefinition[GO:0060559]  
2
  • BHF-UCL
Positive regulation of cell adhesion molecule productiondefinition[GO:0060355]  
1
  • BHF-UCL
Positive regulation of chemokine biosynthetic processdefinition[GO:0045080] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
1
  • Ortholog Compara
Positive regulation of fever generationdefinition[GO:0031622]  
1
  • Ortholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
2
  • UniProtKB
  • AgBase
Positive regulation of granulocyte macrophage colony-stimulating factor productiondefinition[GO:0032725]  
1
  • BHF-UCL
Positive regulation of heterotypic cell-cell adhesiondefinition[GO:0034116]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of histone acetylationdefinition[GO:0035066]  
1
  • BHF-UCL
Positive regulation of histone phosphorylationdefinition[GO:0033129]  
1
  • BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • RefGenome
Positive regulation of immature T cell proliferation in thymusdefinition[GO:0033092] silver  
1
  • Ortholog Compara
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
1
  • BHF-UCL
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086]  
1
  • BHF-UCL
Positive regulation of interleukin-6 biosynthetic processdefinition[GO:0045410] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • BHF-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • UniProtKB
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • RefGenome
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
1
  • Ortholog Compara
Positive regulation of lipid catabolic processdefinition[GO:0050996]  
1
  • BHF-UCL
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • BHF-UCL
Positive regulation of mitotic nuclear divisiondefinition[GO:0045840]  
1
  • BHF-UCL
Positive regulation of monocyte chemotactic protein-1 productiondefinition[GO:0071639]  
1
  • UniProtKB
Positive regulation of myosin light chain kinase activitydefinition[GO:0035505]  
1
  • BHF-UCL
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023] silver  
1
  • Ortholog Compara
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346]  
1
  • BHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
2
  • BHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • BHF-UCL
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • AgBase
Positive regulation of prostaglandin secretiondefinition[GO:0032308]  
1
  • Ortholog Curator
Positive regulation of protein export from nucleusdefinition[GO:0046827]  
1
  • BHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
2
  • BHF-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • BHF-UCL
Positive regulation of T cell mediated immunitydefinition[GO:0002711]  
1
  • BHF-UCL
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Positive regulation of vascular endothelial growth factor productiondefinition[GO:0010575]  
2
  • BHF-UCL
  • Ortholog Curator
Positive regulation of vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0030949]  
1
  • BHF-UCL
Protein kinase B signalingdefinition[GO:0043491]  
1
  • UniProtKB
Purine nucleobase metabolic processdefinition[GO:0006144] silver  
1
  • Ortholog Compara
Regulation of establishment of endothelial barrierdefinition[GO:1903140]  
1
  • UniProtKB
Regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043122]  
1
  • BHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • BHF-UCL
Response to ATPdefinition[GO:0033198] silver  
1
  • Ortholog Compara
Response to dexamethasonedefinition[GO:0071548] silver  
1
  • Ortholog Compara
Response to diureticdefinition[GO:0036270] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
1
  • Ortholog Compara
Response to heatdefinition[GO:0009408] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to L-ascorbic aciddefinition[GO:0033591] silver  
1
  • Ortholog Compara
Response to morphinedefinition[GO:0043278] silver  
1
  • Ortholog Compara
Response to ozonedefinition[GO:0010193] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Response to statindefinition[GO:0036273] silver  
1
  • Ortholog Compara
Response to stilbenoiddefinition[GO:0035634] silver  
1
  • Ortholog Compara
Response to vitamin Ddefinition[GO:0033280] silver  
1
  • Ortholog Compara
Sequestering of triglyceridedefinition[GO:0030730]  
1
  • BHF-UCL
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Smooth muscle adaptationdefinition[GO:0014805]  
1
  • BHF-UCL
Social behaviordefinition[GO:0035176] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3553  
Alzheimer's disease  hsa05010+3553  
Amoebiasis  hsa05146+3553  
Apoptosis  hsa04210+3553  
Chagas disease (American trypanosomiasis)  hsa05142+3553  
Cytokine-cytokine receptor interaction  hsa04060+3553  
Cytosolic DNA-sensing pathway  hsa04623+3553  
Hematopoietic cell lineage  hsa04640+3553  
Legionellosis  hsa05134+3553  
Leishmaniasis  hsa05140+3553  
Malaria  hsa05144+3553  
MAPK signaling pathway  hsa04010+3553  
NOD-like receptor signaling pathway  hsa04621+3553  
Osteoclast differentiation  hsa04380+3553  
Pertussis  hsa05133+3553  
Prion diseases  hsa05020+3553  
Salmonella infection  hsa05132+3553  
Toll-like receptor signaling pathway  hsa04620+3553  
Tuberculosis  hsa05152+3553  
Type I diabetes mellitus  hsa04940+3553  
According to Reactome, this protein belongs to the following pathways:
CLEC7A/inflammasome pathway  R-HSA-5660668  
Interleukin-1 processing  R-HSA-448706  
Interleukin-1 signaling  R-HSA-446652  
Note 
The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.  
2
  • UniProtKB
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Mitogen  definition   [KW-0497]
Pyrogen  definition   [KW-0666]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: IL1B
GenomeRNAi: 3553
PRO: PR:P01584
Chemistry
GuidetoPHARMACOLOGY: 2623