IL1B - Interleukin-1 beta - human protein (Function)
 
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IL1B »  Interleukin-1 beta  (IL-1 beta)
 
Protein also known as:  Catabolin.
Gene name:  IL1B
Family name: IL-1
Entry whose protein(s) existence is based on evidence at protein level
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1 1067 1
GENE REF ISO

Function

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Overview 
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
2
  • IDABHF-UCL
Interleukin-1 receptor bindingdefinition[GO:0005149]  
1
  • NASUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDABHF-UCL
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular response to drugdefinition[GO:0035690]  
1
  • IDAMGI
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Cellular response to organic cyclic compounddefinition[GO:0071407]  
1
  • IDAUniProtKB
Cellular response to organic substancedefinition[GO:0071310]  
1
  • IDAMGI
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IDABHF-UCL
Ectopic germ cell programmed cell deathdefinition[GO:0035234] silver  
  • IEAOrtholog Compara
Embryo implantationdefinition[GO:0007566]  
1
  • TASBHF-UCL
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Fever generationdefinition[GO:0001660]  
  • IEAUniProtKB KW
Hyaluronan biosynthetic processdefinition[GO:0030213]  
1
  • IDAUniProtKB
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Inflammatory responsedefinition[GO:0006954]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Interleukin-1 beta productiondefinition[GO:0032611] silver  
  • IEAOrtholog Compara
Lipopolysaccharide-mediated signaling pathwaydefinition[GO:0031663]  
1
  • IDAUniProtKB
MAPK cascadedefinition[GO:0000165]  
1
  • IMPUniProtKB
Monocyte aggregationdefinition[GO:0070487]  
1
  • IDAUniProtKB
Negative regulation of adiponectin secretiondefinition[GO:0070164]  
1
  • ISSBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDABHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • IDABHF-UCL
Negative regulation of glucose transportdefinition[GO:0010829]  
1
  • ISSBHF-UCL
Negative regulation of insulin receptor signaling pathwaydefinition[GO:0046627]  
1
  • ISSBHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • IDABHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • ISSBHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • ISSBHF-UCL
Neutrophil chemotaxisdefinition[GO:0030593] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
  • ISSOrtholog Curator
Positive regulation of calcidiol 1-monooxygenase activitydefinition[GO:0060559]  
2
  • IDABHF-UCL
Positive regulation of cell adhesion molecule productiondefinition[GO:0060355]  
1
  • NASBHF-UCL
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of chemokine biosynthetic processdefinition[GO:0045080] silver  
  • IEAOrtholog Compara
Positive regulation of fever generationdefinition[GO:0031622]  
  • ISSOrtholog Curator
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IDAAgBase
Positive regulation of granulocyte macrophage colony-stimulating factor productiondefinition[GO:0032725]  
1
  • IDABHF-UCL
Positive regulation of heterotypic cell-cell adhesiondefinition[GO:0034116]  
2
  • NASBHF-UCL
  • IDAUniProtKB
Positive regulation of histone acetylationdefinition[GO:0035066]  
1
  • NASBHF-UCL
Positive regulation of histone phosphorylationdefinition[GO:0033129]  
1
  • NASBHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123] silver  
  • IEAOrtholog Compara
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
1
  • IDABHF-UCL
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086]  
1
  • IMPBHF-UCL
Positive regulation of interleukin-6 biosynthetic processdefinition[GO:0045410] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • TASBHF-UCL
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IDAUniProtKB
Positive regulation of JNK cascadedefinition[GO:0046330] silver  
  • IEAOrtholog Compara
Positive regulation of lipid catabolic processdefinition[GO:0050996]  
1
  • ISSBHF-UCL
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • IDABHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • IMPBHF-UCL
Positive regulation of monocyte chemotactic protein-1 productiondefinition[GO:0071639]  
1
  • IDAUniProtKB
Positive regulation of myosin light chain kinase activitydefinition[GO:0035505]  
1
  • IDABHF-UCL
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346]  
1
  • IDABHF-UCL
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
2
  • IDABHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • IDABHF-UCL
Positive regulation of prostaglandin secretiondefinition[GO:0032308]  
  • ISSOrtholog Curator
Positive regulation of protein export from nucleusdefinition[GO:0046827]  
1
  • NASBHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
2
  • NASBHF-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of T cell mediated immunitydefinition[GO:0002711]  
1
  • ICBHF-UCL
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Positive regulation of vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0030949]  
1
  • ICBHF-UCL
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Protein kinase B signalingdefinition[GO:0043491]  
1
  • IMPUniProtKB
Regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043122]  
1
  • IDABHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • IDABHF-UCL
Response to ATPdefinition[GO:0033198] silver  
  • IEAOrtholog Compara
Response to carbohydratedefinition[GO:0009743] silver  
  • IEAOrtholog Compara
Sequestering of triglyceridedefinition[GO:0030730]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Smooth muscle adaptationdefinition[GO:0014805]  
1
  • NASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3553  
Alzheimer's disease  hsa05010+3553  
Amoebiasis  hsa05146+3553  
Apoptosis  hsa04210+3553  
Chagas disease (American trypanosomiasis)  hsa05142+3553  
Cytokine-cytokine receptor interaction  hsa04060+3553  
Cytosolic DNA-sensing pathway  hsa04623+3553  
Hematopoietic cell lineage  hsa04640+3553  
Legionellosis  hsa05134+3553  
Leishmaniasis  hsa05140+3553  
Malaria  hsa05144+3553  
MAPK signaling pathway  hsa04010+3553  
NOD-like receptor signaling pathway  hsa04621+3553  
Osteoclast differentiation  hsa04380+3553  
Pertussis  hsa05133+3553  
Prion diseases  hsa05020+3553  
Salmonella infection  hsa05132+3553  
Toll-like receptor signaling pathway  hsa04620+3553  
Tuberculosis  hsa05152+3553  
Type I diabetes mellitus  hsa04940+3553  
According to Reactome, this protein belongs to the following pathways:
Interleukin-1 processing  REACT_23950  
Interleukin-1 signaling  REACT_22442  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Mitogen  definition   [KW-0497]
Pyrogen  definition   [KW-0666]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: IL1B
GenomeRNAi: 3553
PRO: PR:P01584
Chemistry
GuidetoPHARMACOLOGY: 2623