EPO - Erythropoietin - human protein (Function)
 
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EPO »  Erythropoietin
 
Protein also known as:  International Nonproprietary Name Epoetin.
Gene name:  EPO
Family name: EPO/TPO
Entry whose protein(s) existence is based on evidence at protein level
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1 253 1
GENE REF ISO

Function

 show evidences
Overview 
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.  
  • CuratedUniProtKB
GO molecular function 
Erythropoietin receptor bindingdefinition[GO:0005128] silver  
  • IEAInterPro 2 GO
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activator activitydefinition[GO:0030295] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Blood circulationdefinition[GO:0008015]  
1
  • NASPINC
Cellular hyperosmotic responsedefinition[GO:0071474]  
1
  • IDABHF-UCL
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Erythrocyte maturationdefinition[GO:0043249]  
  • IEAUniProtKB KW
Hemoglobin biosynthetic processdefinition[GO:0042541] silver  
  • IEAOrtholog Compara
Negative regulation of calcium ion transport into cytosoldefinition[GO:0010523]  
1
  • IDABHF-UCL
Negative regulation of cation channel activitydefinition[GO:2001258]  
1
  • IDABHF-UCL
Negative regulation of erythrocyte apoptotic processdefinition[GO:1902251]  
1
  • IDABHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressdefinition[GO:1902219]  
1
  • IDABHF-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDABHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • IDABHF-UCL
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of Ras protein signal transductiondefinition[GO:0046579]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
1
  • IDABHF-UCL
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to interleukin-1definition[GO:0070555] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to salt stressdefinition[GO:0009651] silver  
  • IEAOrtholog Compara
Response to testosteronedefinition[GO:0033574] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+2056  
Hematopoietic cell lineage  hsa04640+2056  
Jak-STAT signaling pathway  hsa04630+2056  
According to Reactome, this protein belongs to the following pathway:
Cellular responses to stress  REACT_120956  
 

Keywords

Biological process 
Erythrocyte maturation  definition   [KW-0265]
Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Erythropoietin
GenomeRNAi: 2056
PRO: PR:P01588