IL2RA - Interleukin-2 receptor subunit alpha - human protein (Function)
 
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IL2RA »  Interleukin-2 receptor subunit alpha  (IL2-RA)
 
Protein also known as:  TAC antigen; CD antigen CD25.
Gene name:  IL2RA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T cells.  
3
  • UniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144] silver  
1
  • Ortholog Compara
Interleukin-2 bindingdefinition[GO:0019976]  
1
  • RefGenome
Interleukin-2 receptor activitydefinition[GO:0004911] silver  
1
  • Ortholog Compara
GO biological process 
Activation-induced cell death of T cellsdefinition[GO:0006924] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • PINC
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Immune responsedefinition[GO:0006955]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954]  
1
  • RefGenome
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
1
  • Ortholog Compara
Interleukin-2-mediated signaling pathwaydefinition[GO:0038110] silver  
1
  • Ortholog Compara
Negative regulation of defense response to virusdefinition[GO:0050687] silver  
1
  • Ortholog Compara
Negative regulation of immune responsedefinition[GO:0050777] silver  
1
  • Ortholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
1
  • Ortholog Compara
Notch signaling pathwaydefinition[GO:0007219] silver  
1
  • Ortholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104] silver  
1
  • Ortholog Compara
Positive regulation of T cell differentiationdefinition[GO:0045582] silver  
1
  • Ortholog Compara
Regulation of T cell homeostatic proliferationdefinition[GO:0046013] silver  
1
  • Ortholog Compara
Regulation of T cell tolerance inductiondefinition[GO:0002664]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3559  
Endocytosis  hsa04144+3559  
Hematopoietic cell lineage  hsa04640+3559  
HTLV-I infection  hsa05166+3559  
Jak-STAT signaling pathway  hsa04630+3559  
Measles  hsa05162+3559  
According to Reactome, this protein belongs to the following pathways:
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GPVI-mediated activation cascade  R-HSA-114604  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-2 signaling  R-HSA-451927  
RAF/MAP kinase cascade  R-HSA-5673001  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: IL2RA
GenomeRNAi: 3559
PRO: PR:P01589
Chemistry
GuidetoPHARMACOLOGY: 1695