IL2RA - Interleukin-2 receptor subunit alpha - human protein (Function)
 
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IL2RA »  Interleukin-2 receptor subunit alpha  (IL2-RA)
 
Protein also known as:  TAC antigen; CD antigen CD25.
Gene name:  IL2RA
Entry whose protein(s) existence is based on evidence at protein level
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1 237 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for interleukin-2.  
  • CuratedUniProtKB
GO molecular function 
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Interleukin-2 bindingdefinition[GO:0019976] silver  
  • IEAOrtholog Compara
Interleukin-2 receptor activitydefinition[GO:0004911] silver  
  • IEAOrtholog Compara
GO biological process 
Activation-induced cell death of T cellsdefinition[GO:0006924] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory response to antigenic stimulusdefinition[GO:0002437] silver  
  • IEAOrtholog Compara
Negative regulation of defense response to virusdefinition[GO:0050687] silver  
  • IEAOrtholog Compara
Negative regulation of immune responsedefinition[GO:0050777] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Notch signaling pathwaydefinition[GO:0007219] silver  
  • IEAOrtholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104] silver  
  • IEAOrtholog Compara
Positive regulation of T cell differentiationdefinition[GO:0045582] silver  
  • IEAOrtholog Compara
Regulation of T cell homeostatic proliferationdefinition[GO:0046013] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3559  
Endocytosis  hsa04144+3559  
Hematopoietic cell lineage  hsa04640+3559  
HTLV-I infection  hsa05166+3559  
Jak-STAT signaling pathway  hsa04630+3559  
Measles  hsa05162+3559  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: IL2RA
GenomeRNAi: 3559
PRO: PR:P01589
Chemistry
GuidetoPHARMACOLOGY: 1695