IL2RA - Interleukin-2 receptor subunit alpha - human protein (Medical)
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IL2RA »  Interleukin-2 receptor subunit alpha  (IL2-RA)
Protein also known as:  TAC antigen; CD antigen CD25.
Gene name:  IL2RA
Entry whose protein(s) existence is based on evidence at protein level
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1 298 1

Displayed isoform: Iso 1



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Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Disease susceptibility is associated with variations affecting the gene represented in this entry.  
  • UniProtKB
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41) [MIM:606367]: A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions. The disease is caused by mutations affecting the gene represented in this entry.  
  • UniProtKB
According to Orphanet, this protein is involved in the following diseases:
Immunodeficiency due to CD25 deficiency  169100  
Juvenile rheumatoid factor-negative polyarthritis  85408  
Oligoarticular juvenile arthritis  85410  
According to DrugBank, this protein binds/interacts with the following drugs:
Aldesleukin  DB00041  
Basiliximab  DB00074  
Daclizumab  DB00111  
Denileukin diftitox  DB00004  


Diabetes mellitus  definition   [KW-0219]
Disease mutation  definition   [KW-0225]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 3559
MalaCards: IL2RA
MIM: 601942
MIM: 606367
PharmGKB: PA29828
Polymorphism and mutation databases
BioMuta: IL2RA
DMDM: 124317
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.