IL2RA - Interleukin-2 receptor subunit alpha - human protein (Medical)
 
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IL2RA »  Interleukin-2 receptor subunit alpha  (IL2-RA)
 
Protein also known as:  TAC antigen; CD antigen CD25.
Gene name:  IL2RA
Entry whose protein(s) existence is based on evidence at protein level
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1 237 1
GENE REF ISO

Medical

 show evidences
Disease 
Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Disease susceptibility is associated with variations affecting the gene represented in this entry.  
  • CuratedUniProtKB
According to Orphanet, this protein is involved in the following diseases:
Immunodeficiency due to CD25 deficiency  169100  
Juvenile rheumatoid factor-negative polyarthritis  85408  
Oligoarticular juvenile arthritis  85410  
Pharmaceutical 
According to DrugBank, this protein binds/interacts with the following drugs:
Aldesleukin  DB00041  
Basiliximab  DB00074  
Daclizumab  DB00111  
Denileukin diftitox  DB00004  
 

Keywords

Disease 
Diabetes mellitus  definition   [KW-0219]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Organism-specific databases
CTD: 3559
MIM: 601942
MIM: 606367 [ phenotype ]
PharmGKB: PA29828
Polymorphism databases
DMDM: 124317
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.