IGHA1 - Ig alpha-1 chain C region - human protein (Function)
 
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IGHA1 »  Ig alpha-1 chain C region
 
Gene name:  IGHA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.  
1
  • UniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823]  
2
  • UniProtKB
  • RefGenome
Contributes to immunoglobulin receptor bindingdefinition[GO:0034987]  
1
  • UniProtKB
GO biological process 
Antibacterial humoral responsedefinition[GO:0019731]  
1
  • UniProtKB
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • RefGenome
Complement activation, classical pathwaydefinition[GO:0006958]  
1
  • RefGenome
Fc-epsilon receptor signaling pathwaydefinition[GO:0038095]  
1
  • RefGenome
Fc-gamma receptor signaling pathway involved in phagocytosisdefinition[GO:0038096]  
1
  • RefGenome
Glomerular filtrationdefinition[GO:0003094]  
1
  • UniProtKB
Immune responsedefinition[GO:0006955]  
1
  • UniProtKB
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Phagocytosis, engulfmentdefinition[GO:0006911]  
1
  • RefGenome
Phagocytosis, recognitiondefinition[GO:0006910]  
1
  • RefGenome
Positive regulation of B cell activationdefinition[GO:0050871]  
1
  • RefGenome
Positive regulation of respiratory burstdefinition[GO:0060267]  
1
  • UniProtKB
Protein-chromophore linkagedefinition[GO:0018298]  
1
  • UniProtKB KW
Retina homeostasisdefinition[GO:0001895]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Scavenging of heme from plasma  R-HSA-2168880  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links