COL1A1 - Collagen alpha-1(I) chain - human protein (Function)
 
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COL1A1 »  Collagen alpha-1(I) chain
 
Protein also known as:  Alpha-1 type I collagen.
Gene name:  COL1A1
Family name: Fibrillar collagen
Entry whose protein(s) existence is based on evidence at protein level
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1 391 1
GENE REF ISO

Function

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Overview 
Type I collagen is a member of group I collagen (fibrillar forming collagen).  
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Blood vessel developmentdefinition[GO:0001568]  
1
  • IMPUniProtKB
Bone trabecula formationdefinition[GO:0060346] silver  
  • IEAOrtholog Compara
Cartilage development involved in endochondral bone morphogenesisdefinition[GO:0060351] silver  
  • IEAOrtholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
  • IEAOrtholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560] silver  
  • IEAOrtholog Compara
Collagen biosynthetic processdefinition[GO:0032964]  
1
  • IMPUniProtKB
Collagen fibril organizationdefinition[GO:0030199]  
4
  • IMPUniProtKB
Embryonic skeletal system developmentdefinition[GO:0048706]  
1
  • IMPUniProtKB
Endochondral ossificationdefinition[GO:0001958] silver  
  • IEAOrtholog Compara
Face morphogenesisdefinition[GO:0060325] silver  
  • IEAOrtholog Compara
Intramembranous ossificationdefinition[GO:0001957] silver  
  • IEAOrtholog Compara
Negative regulation of cell-substrate adhesiondefinition[GO:0010812] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IDAUniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDAUniProtKB
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein heterotrimerizationdefinition[GO:0070208] silver  
  • IEAOrtholog Compara
Protein localization to nucleusdefinition[GO:0034504]  
1
  • IDAUniProtKB
Protein transportdefinition[GO:0015031] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to corticosteroiddefinition[GO:0031960] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Sensory perception of sounddefinition[GO:0007605]  
1
  • IMPUniProtKB
Skeletal system developmentdefinition[GO:0001501]  
3
  • IMPUniProtKB
  • IMPMGI
Skin morphogenesisdefinition[GO:0043589]  
1
  • IMPUniProtKB
Tooth mineralizationdefinition[GO:0034505]  
1
  • IMPUniProtKB
Visual perceptiondefinition[GO:0007601]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1277  
ECM-receptor interaction  hsa04512+1277  
Focal adhesion  hsa04510+1277  
Protein digestion and absorption  hsa04974+1277  
According to Reactome, this protein belongs to the following pathways:
Binding and Uptake of Ligands by Scavenger Receptors  REACT_160300  
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Collagen,_type_I,_alpha_1
GenomeRNAi: 1277
PRO: PR:P02452