COL3A1 - Collagen alpha-1(III) chain - human protein (Function)
 
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COL3A1 »  Collagen alpha-1(III) chain
 
Gene name:  COL3A1
Family name: Fibrillar collagen
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 189 2
GENE REF ISO

Function

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Overview 
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.  
1
  • UniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201]  
2
  • UniProtKB
Integrin bindingdefinition[GO:0005178]  
2
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
SMAD bindingdefinition[GO:0046332] silver  
1
  • Ortholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Aorta smooth muscle tissue morphogenesisdefinition[GO:0060414] silver  
1
  • Ortholog Compara
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • UniProtKB
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Cerebral cortex developmentdefinition[GO:0021987]  
1
  • Ortholog Curator
Collagen fibril organizationdefinition[GO:0030199]  
3
  • UniProtKB
Digestive tract developmentdefinition[GO:0048565] silver  
1
  • Ortholog Compara
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • UniProtKB
Heart developmentdefinition[GO:0007507]  
1
  • UniProtKB
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • UniProtKB
Negative regulation of immune responsedefinition[GO:0050777]  
1
  • UniProtKB
Negative regulation of neuron migrationdefinition[GO:2001223]  
1
  • Ortholog Curator
Peptide cross-linkingdefinition[GO:0018149]  
1
  • UniProtKB
Platelet activationdefinition[GO:0030168]  
1
  • UniProtKB
Positive regulation of Rho protein signal transductiondefinition[GO:0035025]  
1
  • Ortholog Curator
Response to cytokinedefinition[GO:0034097]  
2
  • UniProtKB
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Response to radiationdefinition[GO:0009314]  
1
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501] silver  
1
  • Ortholog Compara
Skin developmentdefinition[GO:0043588]  
1
  • UniProtKB
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • UniProtKB
Wound healingdefinition[GO:0042060]  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1281  
ECM-receptor interaction  hsa04512+1281  
Focal adhesion  hsa04510+1281  
Protein digestion and absorption  hsa04974+1281  
According to Reactome, this protein belongs to the following pathways:
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen biosynthesis and modifying enzymes  REACT_121139  
Collagen degradation  REACT_150401  
ECM proteoglycans  REACT_163906  
Extracellular matrix organization  REACT_118779  
Integrin cell surface interactions  REACT_13552  
NCAM1 interactions  REACT_18312  
Non-integrin membrane-ECM interactions  REACT_163874  
Scavenging by Class A Receptors  REACT_163699  
Signaling by PDGF  REACT_16888  
Syndecan interactions  REACT_163942  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links