COL3A1 - Collagen alpha-1(III) chain - human protein (Function)
 
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COL3A1 »  Collagen alpha-1(III) chain
 
Gene name:  COL3A1
Family name: Fibrillar collagen
Entry whose protein(s) existence is based on evidence at protein level
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1 174 2
GENE REF ISO

Function

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Overview 
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.  
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201]  
2
  • IMPUniProtKB
Integrin bindingdefinition[GO:0005178]  
2
  • NASUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
SMAD bindingdefinition[GO:0046332] silver  
  • IEAOrtholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • IDAUniProtKB
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Cerebral cortex developmentdefinition[GO:0021987]  
  • ISSOrtholog Curator
Collagen fibril organizationdefinition[GO:0030199]  
3
  • IMPUniProtKB
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • IMPUniProtKB
Heart developmentdefinition[GO:0007507]  
1
  • IMPUniProtKB
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • IMPUniProtKB
Negative regulation of immune responsedefinition[GO:0050777]  
1
  • IMPUniProtKB
Negative regulation of neuron migrationdefinition[GO:2001223]  
  • ISSOrtholog Curator
Peptide cross-linkingdefinition[GO:0018149]  
1
  • IDAUniProtKB
Platelet activationdefinition[GO:0030168]  
1
  • NASUniProtKB
Positive regulation of Rho protein signal transductiondefinition[GO:0035025]  
  • ISSOrtholog Curator
Response to cytokinedefinition[GO:0034097]  
2
  • IDAUniProtKB
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to radiationdefinition[GO:0009314]  
1
  • IDAUniProtKB
Skeletal system developmentdefinition[GO:0001501] silver  
  • IEAOrtholog Compara
Skin developmentdefinition[GO:0043588]  
1
  • IMPUniProtKB
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDAUniProtKB
Wound healingdefinition[GO:0042060]  
2
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1281  
ECM-receptor interaction  hsa04512+1281  
Focal adhesion  hsa04510+1281  
Protein digestion and absorption  hsa04974+1281  
According to Reactome, this protein belongs to the following pathways:
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen biosynthesis and modifying enzymes  REACT_121139  
Collagen degradation  REACT_150401  
ECM proteoglycans  REACT_163906  
Extracellular matrix organization  REACT_118779  
Integrin cell surface interactions  REACT_13552  
NCAM1 interactions  REACT_18312  
Non-integrin membrane-ECM interactions  REACT_163874  
Scavenging by Class A Receptors  REACT_163699  
Signaling by PDGF  REACT_16888  
Syndecan interactions  REACT_163942  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links