COL4A1 - Collagen alpha-1(IV) chain - human protein (Function)
 
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COL4A1 »  Collagen alpha-1(IV) chain
 
Cleaved into:  Arresten.
Gene name:  COL4A1
Family name: Type IV collagen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.  
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  • UniProtKB
Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.  
1
  • UniProtKB
GO molecular function 
Extracellular matrix constituent conferring elasticitydefinition[GO:0030023]  
1
  • BHF-UCL
Extracellular matrix structural constituentdefinition[GO:0005201]  
2
  • BHF-UCL
Platelet-derived growth factor bindingdefinition[GO:0048407]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Basement membrane organizationdefinition[GO:0071711]  
3
  • BHF-UCL
Blood vessel morphogenesisdefinition[GO:0048514]  
1
  • BHF-UCL
Brain developmentdefinition[GO:0007420]  
1
  • BHF-UCL
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Epithelial cell differentiationdefinition[GO:0030855] silver  
1
  • Ortholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
1
  • Ortholog Compara
Patterning of blood vesselsdefinition[GO:0001569]  
1
  • BHF-UCL
Renal tubule morphogenesisdefinition[GO:0061333]  
1
  • BHF-UCL
Retinal blood vessel morphogenesisdefinition[GO:0061304]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1282  
ECM-receptor interaction  hsa04512+1282  
Focal adhesion  hsa04510+1282  
Pathways in cancer  hsa05200+1282  
Protein digestion and absorption  hsa04974+1282  
Small cell lung cancer  hsa05222+1282  
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  R-HSA-2214320  
Assembly of collagen fibrils and other multimeric structures  R-HSA-2022090  
Collagen biosynthesis and modifying enzymes  R-HSA-1650814  
Collagen degradation  R-HSA-1442490  
ECM proteoglycans  R-HSA-3000178  
Extracellular matrix organization  R-HSA-1474244  
Integrin cell surface interactions  R-HSA-216083  
Laminin interactions  R-HSA-3000157  
NCAM1 interactions  R-HSA-419037  
Non-integrin membrane-ECM interactions  R-HSA-3000171  
Scavenging by Class A Receptors  R-HSA-3000480  
Signaling by PDGF  R-HSA-186797  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Collagen,_type_IV,_alpha_1
GenomeRNAi: 1282
PRO: PR:P02462