CRYAB - Alpha-crystallin B chain - human protein (Function)
 
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CRYAB »  Alpha-crystallin B chain
 
Protein also known as:  Renal carcinoma antigen NY-REN-27.
Gene name:  CRYAB
Entry whose protein(s) existence is based on evidence at protein level
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1 211 1
GENE REF ISO

Function

 show evidences
Overview 
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Microtubule bindingdefinition[GO:0008017] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIHGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Structural constituent of eye lensdefinition[GO:0005212]  
  • IEAUniProtKB KW
Unfolded protein bindingdefinition[GO:0051082]  
1
  • IPIUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic process involved in morphogenesisdefinition[GO:0060561] silver  
  • IEAOrtholog Compara
Cellular response to gamma radiationdefinition[GO:0071480]  
1
  • IMPMGI
Glucose metabolic processdefinition[GO:0006006] silver  
  • IEAOrtholog Compara
Lens development in camera-type eyedefinition[GO:0002088] silver  
  • IEAOrtholog Compara
Microtubule polymerization or depolymerizationdefinition[GO:0031109] silver  
  • IEAOrtholog Compara
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Muscle organ developmentdefinition[GO:0007517] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAHGNC
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
  • IEAOrtholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
  • IEAOrtholog Compara
Negative regulation of intracellular transportdefinition[GO:0032387]  
1
  • IDAHGNC
Negative regulation of reactive oxygen species metabolic processdefinition[GO:2000378] silver  
  • IEAOrtholog Compara
Protein foldingdefinition[GO:0006457] silver  
  • IEAOrtholog Compara
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Regulation of cell deathdefinition[GO:0010941]  
1
  • IMPMGI
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Stress-activated MAPK cascadedefinition[GO:0051403] silver  
  • IEAOrtholog Compara
Tubulin complex assemblydefinition[GO:0007021] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+1410  
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Eye lens protein  definition   [KW-0273]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CRYAB
GenomeRNAi: 1410
PRO: PR:P02511