KRT6A - Keratin, type II cytoskeletal 6A - human protein (Function)
 
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KRT6A »  Keratin, type II cytoskeletal 6A
 
Protein also known as:  Type-II keratin Kb6; Allergen Hom s 5.
Gene name:  KRT6A
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • HGNC
Structural constituent of cytoskeletondefinition[GO:0005200]  
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  • UniProtKB
GO biological process 
Cell differentiationdefinition[GO:0030154]  
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  • UniProtKB
Mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
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  • ParkinsonsUK-UCL
Morphogenesis of an epitheliumdefinition[GO:0002009]  
1
  • Ortholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • ParkinsonsUK-UCL
Wound healingdefinition[GO:0042060]  
1
  • Ortholog Curator
Xenophagydefinition[GO:0098792]  
1
  • ParkinsonsUK-UCL
Allergen 
Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.  
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  • UniProtKB
Note 
There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.  
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  • UniProtKB
There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Keratin_6A
GenomeRNAi: 3853
PRO: PR:P02538