KRT6A - Keratin, type II cytoskeletal 6A - human protein (Function)
 
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KRT6A »  Keratin, type II cytoskeletal 6A
 
Protein also known as:  Type-II keratin Kb6; Allergen Hom s 5.
Gene name:  KRT6A
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • HGNC
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • UniProtKB
GO biological process 
Activation of mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
1
  • ParkinsonsUK-UCL
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB
Morphogenesis of an epitheliumdefinition[GO:0002009]  
1
  • Ortholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • ParkinsonsUK-UCL
Wound healingdefinition[GO:0042060]  
1
  • Ortholog Curator
Allergen 
Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.  
1
  • UniProtKB
Note 
There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.  
1
  • UniProtKB
There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Keratin_6A
GenomeRNAi: 3853
PRO: PR:P02538