LMNA - Prelamin-A/C - human protein (Function)
 
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LMNA »  Prelamin-A/C
 
Cleaved into:  Lamin-A/C.
Gene name:  LMNA
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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1 475 6
GENE REF ISO

Function

 show evidences
Overview 
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.  
2
  • CuratedUniProtKB
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
13
  • IPIUniProtKB
  • IPIIntAct
  • IPIHGNC
Structural molecule activitydefinition[GO:0005198]  
2
  • TASUniProtKB
  • IEAInterPro 2 GO
GO biological process 
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • IEPUniProtKB
Establishment or maintenance of microtubule cytoskeleton polaritydefinition[GO:0030951]  
  • ISSOrtholog Curator
Isoforms  A and C   Muscle organ developmentdefinition[GO:0007517]  
1
  • IMPUniProtKB
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237] silver  
  • IEAOrtholog Compara
Negative regulation of release of cytochrome c from mitochondriadefinition[GO:0090201] silver  
  • IEAOrtholog Compara
Positive regulation of cell agingdefinition[GO:0090343]  
1
  • IDAUniProtKB
Protein localization to nucleusdefinition[GO:0034504]  
  • ISSOrtholog Curator
Regulation of cell migrationdefinition[GO:0030334]  
  • ISSOrtholog Curator
Sterol regulatory element binding protein import into nucleusdefinition[GO:0035105] silver  
  • IEAOrtholog Compara
Ventricular cardiac muscle cell developmentdefinition[GO:0055015] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+4000  
Dilated cardiomyopathy  hsa05414+4000  
Hypertrophic cardiomyopathy (HCM)  hsa05410+4000  
According to Reactome, this protein belongs to the following pathways:
Breakdown of the nuclear lamina  REACT_13472  
Clearance of Nuclear Envelope Membranes from Chromatin  REACT_160251  
Depolymerisation of the Nuclear Lamina  REACT_200828  
Initiation of Nuclear Envelope Reformation  REACT_160242  
Meiotic synapsis  REACT_75792  
XBP1(S) activates chaperone genes  REACT_18273  
Note 
There are three types of lamins in human cells: A, B, and C.  
  • CuratedUniProtKB
The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LMNA
GenomeRNAi: 4000
PRO: PR:P02545