SPTA1 - Spectrin alpha chain, erythrocytic 1 - human protein (Function)
 
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Protein
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References

 
SPTA1 »  Spectrin alpha chain, erythrocytic 1
 
Protein also known as:  Erythroid alpha-spectrin.
Gene name:  SPTA1
Family name: Spectrin
Entry whose protein(s) existence is based on evidence at protein level
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1 101 2
GENE REF ISO

Function

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Overview 
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.  
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
1
  • TASPINC
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
GO biological process 
Actin filament cappingdefinition[GO:0051693]  
  • IEAUniProtKB KW
Actin filament organizationdefinition[GO:0007015]  
1
  • TASPINC
Hemopoiesisdefinition[GO:0030097] silver  
  • IEAOrtholog Compara
Lymphocyte homeostasisdefinition[GO:0002260] silver  
  • IEAOrtholog Compara
Plasma membrane organizationdefinition[GO:0007009] silver  
  • IEAOrtholog Compara
Porphyrin-containing compound biosynthetic processdefinition[GO:0006779] silver  
  • IEAOrtholog Compara
Positive regulation of protein bindingdefinition[GO:0032092] silver  
  • IEAOrtholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
  • IEAOrtholog Compara
Regulation of cell shapedefinition[GO:0008360] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Developmental Biology  REACT_188576  
 

Keywords

Biological process 
Cell shape  definition   [KW-0133]
Molecular function 
Actin capping  definition   [KW-0117]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Spectrin,_alpha_1
GenomeRNAi: 6708
PRO: PR:P02549