SPTA1 - Spectrin alpha chain, erythrocytic 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SPTA1 »  Spectrin alpha chain, erythrocytic 1
 
Protein also known as:  Erythroid alpha-spectrin.
Gene name:  SPTA1
Family name: Spectrin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 112 2
GENE REF ISO

Function

 show evidences
Overview 
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.  
1
  • UniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
1
  • PINC
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • PINC
GO biological process 
Actin filament cappingdefinition[GO:0051693]  
1
  • UniProtKB KW
Actin filament organizationdefinition[GO:0007015]  
1
  • PINC
Hemopoiesisdefinition[GO:0030097] silver  
1
  • Ortholog Compara
Lymphocyte homeostasisdefinition[GO:0002260] silver  
1
  • Ortholog Compara
Plasma membrane organizationdefinition[GO:0007009] silver  
1
  • Ortholog Compara
Porphyrin-containing compound biosynthetic processdefinition[GO:0006779] silver  
1
  • Ortholog Compara
Positive regulation of protein bindingdefinition[GO:0032092] silver  
1
  • Ortholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
1
  • Ortholog Compara
Regulation of cell shapedefinition[GO:0008360] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Interaction between L1 and Ankyrins  REACT_22266  
NCAM signaling for neurite out-growth  REACT_18334  
 

Keywords

Biological process 
Cell shape  definition   [KW-0133]
Molecular function 
Actin capping  definition   [KW-0117]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Spectrin,_alpha_1
GenomeRNAi: 6708
PRO: PR:P02549