APOA1 - Apolipoprotein A-I - human protein (Function)
 
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APOA1 »  Apolipoprotein A-I  (ApoA-I)
 
Protein also known as:  Apolipoprotein A1. Cleaved into:  Proapolipoprotein A-I; Truncated apolipoprotein A-I.
Gene name:  APOA1
Family name: Apolipoprotein A1/A4/E
Entry whose protein(s) existence is based on evidence at protein level
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1 575 1
GENE REF ISO

Function

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Overview 
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.  
2
  • UniProtKB
GO molecular function 
Apolipoprotein A-I receptor bindingdefinition[GO:0034191]  
1
  • BHF-UCL
Apolipoprotein receptor bindingdefinition[GO:0034190]  
1
  • BHF-UCL
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • BHF-UCL
Chemorepellent activitydefinition[GO:0045499]  
1
  • UniProtKB
Cholesterol bindingdefinition[GO:0015485]  
1
  • BHF-UCL
Contributes to cholesterol transporter activitydefinition[GO:0017127]  
2
  • BHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
High-density lipoprotein particle bindingdefinition[GO:0008035] silver  
1
  • Ortholog Compara
High-density lipoprotein particle receptor bindingdefinition[GO:0070653]  
2
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
3
  • IntAct
  • BHF-UCL
Lipase inhibitor activitydefinition[GO:0055102] silver  
1
  • Ortholog Compara
Phosphatidylcholine bindingdefinition[GO:0031210]  
1
  • RefGenome
Phosphatidylcholine-sterol O-acyltransferase activator activitydefinition[GO:0060228]  
1
  • BHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • BHF-UCL
Phospholipid transporter activitydefinition[GO:0005548] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • UniProtKB
  • Alzheimers_University_of_Toronto
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Blood vessel endothelial cell migrationdefinition[GO:0043534] silver  
1
  • Ortholog Compara
Cholesterol biosynthetic processdefinition[GO:0006695]  
1
  • RefGenome
Cholesterol effluxdefinition[GO:0033344]  
5
  • BHF-UCL
  • AgBase
Cholesterol homeostasisdefinition[GO:0042632]  
2
  • BHF-UCL
Cholesterol importdefinition[GO:0070508]  
1
  • BHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • BHF-UCL
Cholesterol transportdefinition[GO:0030301]  
1
  • MGI
Endothelial cell proliferationdefinition[GO:0001935] silver  
1
  • Ortholog Compara
Not  ERK1 and ERK2 cascadedefinition[GO:0070371]  
1
  • UniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • BHF-UCL
Glucocorticoid metabolic processdefinition[GO:0008211] silver  
1
  • Ortholog Compara
High-density lipoprotein particle assemblydefinition[GO:0034380]  
1
  • BHF-UCL
High-density lipoprotein particle clearancedefinition[GO:0034384]  
1
  • BHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • BHF-UCL
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • UniProtKB
Lipid storagedefinition[GO:0019915] silver  
1
  • Ortholog Compara
Lipoprotein biosynthetic processdefinition[GO:0042158] silver  
1
  • Ortholog Compara
Lipoprotein metabolic processdefinition[GO:0042157]  
1
  • RefGenome
Negative chemotaxisdefinition[GO:0050919]  
1
  • UniProtKB
Negative regulation of cell adhesion molecule productiondefinition[GO:0060354]  
1
  • BHF-UCL
Negative regulation of cytokine secretion involved in immune responsedefinition[GO:0002740]  
1
  • BHF-UCL
Negative regulation of heterotypic cell-cell adhesiondefinition[GO:0034115]  
1
  • BHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • BHF-UCL
Negative regulation of interleukin-1 beta secretiondefinition[GO:0050713]  
1
  • BHF-UCL
Negative regulation of lipase activitydefinition[GO:0060192] silver  
1
  • Ortholog Compara
Negative regulation of response to cytokine stimulusdefinition[GO:0060761]  
1
  • BHF-UCL
Negative regulation of tumor necrosis factor-mediated signaling pathwaydefinition[GO:0010804]  
1
  • BHF-UCL
Negative regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010903]  
1
  • BHF-UCL
Neuron projection regenerationdefinition[GO:0031102]  
1
  • RefGenome
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Peptidyl-methionine modificationdefinition[GO:0018206]  
1
  • UniProtKB
Peripheral nervous system axon regenerationdefinition[GO:0014012] silver  
1
  • Ortholog Compara
Phosphatidylcholine biosynthetic processdefinition[GO:0006656]  
1
  • BHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
2
  • BHF-UCL
Phospholipid homeostasisdefinition[GO:0055091]  
1
  • BHF-UCL
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • BHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723]  
1
  • RefGenome
Positive regulation of hydrolase activitydefinition[GO:0051345]  
1
  • BHF-UCL
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
1
  • RefGenome
Positive regulation of Rho protein signal transductiondefinition[GO:0035025]  
1
  • UniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • UniProtKB
Positive regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900026]  
1
  • UniProtKB
Positive regulation of transferase activitydefinition[GO:0051347] silver  
1
  • Ortholog Compara
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • RefGenome
Protein oxidationdefinition[GO:0018158]  
1
  • UniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • BHF-UCL
Regulation of Cdc42 protein signal transductiondefinition[GO:0032489]  
1
  • BHF-UCL
Regulation of intestinal cholesterol absorptiondefinition[GO:0030300]  
1
  • RefGenome
Regulation of protein phosphorylationdefinition[GO:0001932] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • BHF-UCL
Not  Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • UniProtKB
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • BHF-UCL
Vitamin transportdefinition[GO:0051180]  
1
  • AgBase
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+335  
Fat digestion and absorption  hsa04975+335  
PPAR signaling pathway  hsa03320+335  
Vitamin digestion and absorption  hsa04977+335  
According to Reactome, this protein belongs to the following pathways:
ABCA transporters in lipid homeostasis  REACT_111158  
Amyloids  REACT_75925  
Chylomicron-mediated lipid transport  REACT_6841  
HDL-mediated lipid transport  REACT_13621  
Platelet degranulation  REACT_318  
PPARA activates gene expression  REACT_116145  
Retinoid metabolism and transport  REACT_24968  
Scavenging by Class A Receptors  REACT_163699  
Scavenging by Class B Receptors  REACT_163679  
Scavenging of heme from plasma  REACT_160163  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_A1
GenomeRNAi: 335
PRO: PR:P02647