APOE - Apolipoprotein E - human protein (Function)
 
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APOE »  Apolipoprotein E  (Apo-E)
 
Gene name:  APOE
Family name: Apolipoprotein A1/A4/E
Entry whose protein(s) existence is based on evidence at protein level
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1 1236 1
GENE REF ISO

Function

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Overview 
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.  
  • CuratedUniProtKB
GO molecular function 
Antioxidant activitydefinition[GO:0016209]  
1
  • IDABHF-UCL
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • IDAUniProtKB
Cholesterol transporter activitydefinition[GO:0017127] silver  
  • IEAOrtholog Compara
Heparin bindingdefinition[GO:0008201]  
1
  • IDABHF-UCL
Hydroxyapatite bindingdefinition[GO:0046848] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
1
  • IDABHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • IDAUniProtKB
Lipid transporter activitydefinition[GO:0005319]  
1
  • IDABHF-UCL
Lipoprotein particle bindingdefinition[GO:0071813] silver  
  • IEAOrtholog Compara
Low-density lipoprotein particle receptor bindingdefinition[GO:0050750]  
2
  • IPIBHF-UCL
Metal chelating activitydefinition[GO:0046911]  
1
  • IDABHF-UCL
Phosphatidylcholine-sterol O-acyltransferase activator activitydefinition[GO:0060228]  
1
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Tau protein bindingdefinition[GO:0048156]  
1
  • IPIBHF-UCL
Very-low-density lipoprotein particle receptor bindingdefinition[GO:0070326]  
2
  • IPIBHF-UCL
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringdefinition[GO:0097113]  
1
  • IDAAlzheimers_University_of_Toronto
Artery morphogenesisdefinition[GO:0048844] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cellular calcium ion homeostasisdefinition[GO:0006874] silver  
  • IEAOrtholog Compara
Cellular response to cholesteroldefinition[GO:0071397] silver  
  • IEAOrtholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Cellular response to interleukin-1definition[GO:0071347] silver  
  • IEAOrtholog Compara
cGMP-mediated signalingdefinition[GO:0019934]  
1
  • IDABHF-UCL
Cholesterol catabolic processdefinition[GO:0006707] silver  
  • IEAOrtholog Compara
Cholesterol effluxdefinition[GO:0033344]  
2
  • IDABHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IDABHF-UCL
Cholesterol metabolic processdefinition[GO:0008203]  
2
  • IDABHF-UCL
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • IMPBHF-UCL
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • TASUniProtKB
Fatty acid homeostasisdefinition[GO:0055089]  
1
  • IDAAlzheimers_University_of_Toronto
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
High-density lipoprotein particle assemblydefinition[GO:0034380]  
1
  • IDABHF-UCL
High-density lipoprotein particle clearancedefinition[GO:0034384]  
1
  • IDABHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • IGIBHF-UCL
Intracellular transportdefinition[GO:0046907]  
1
  • TASUniProtKB
Lipoprotein biosynthetic processdefinition[GO:0042158] silver  
  • IEAOrtholog Compara
Lipoprotein catabolic processdefinition[GO:0042159] silver  
  • IEAOrtholog Compara
Long-chain fatty acid transportdefinition[GO:0015909]  
1
  • IDAAlzheimers_University_of_Toronto
Low-density lipoprotein particle remodelingdefinition[GO:0034374] silver  
  • IEAOrtholog Compara
Maintenance of location in celldefinition[GO:0051651] silver  
  • IEAOrtholog Compara
N-methyl-D-aspartate receptor clusteringdefinition[GO:0097114]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of beta-amyloid formationdefinition[GO:1902430]  
2
  • IDAAlzheimers_University_of_Toronto
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • IDABHF-UCL
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IDABHF-UCL
Negative regulation of cholesterol biosynthetic processdefinition[GO:0045541]  
1
  • IDABHF-UCL
Negative regulation of cholesterol effluxdefinition[GO:0090370]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of dendritic spine developmentdefinition[GO:0061000]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of dendritic spine maintenancedefinition[GO:1902951]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • IDABHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • ICBHF-UCL
Negative regulation of lipid biosynthetic processdefinition[GO:0051055]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of lipid transport across blood brain barrierdefinition[GO:1903001]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IDABHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of phospholipid effluxdefinition[GO:1902999]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of platelet activationdefinition[GO:0010544]  
1
  • IDABHF-UCL
Negative regulation of postsynaptic membrane organizationdefinition[GO:1901627]  
1
  • IDAAlzheimers_University_of_Toronto
Negative regulation of presynaptic membrane organizationdefinition[GO:1901630]  
1
  • IDAAlzheimers_University_of_Toronto
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • IDABHF-UCL
Oligodendrocyte differentiationdefinition[GO:0048709] silver  
  • IEAOrtholog Compara
Peripheral nervous system axon regenerationdefinition[GO:0014012] silver  
  • IEAOrtholog Compara
Phospholipid effluxdefinition[GO:0033700]  
1
  • IDABHF-UCL
Positive regulation of axon extensiondefinition[GO:0045773] silver  
  • IEAOrtholog Compara
Positive regulation of beta-amyloid formationdefinition[GO:1902004]  
2
  • IDAAlzheimers_University_of_Toronto
Positive regulation of cGMP biosynthetic processdefinition[GO:0030828]  
1
  • IDABHF-UCL
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
3
  • IDABHF-UCL
  • IDAAlzheimers_University_of_Toronto
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • IDABHF-UCL
Positive regulation of dendritic spine developmentdefinition[GO:0060999]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of dendritic spine maintenancedefinition[GO:1902952]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of lipid biosynthetic processdefinition[GO:0046889]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of lipid transport across blood brain barrierdefinition[GO:1903002]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of low-density lipoprotein particle receptor catabolic processdefinition[GO:0032805]  
1
  • IDABHF-UCL
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • IDABHF-UCL
Positive regulation of neurofibrillary tangle assemblydefinition[GO:1902998]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of neuron deathdefinition[GO:1901216]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • IDABHF-UCL
Positive regulation of phospholipid effluxdefinition[GO:1902995]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of postsynaptic membrane organizationdefinition[GO:1901628]  
1
  • IDAAlzheimers_University_of_Toronto
Positive regulation of presynaptic membrane organizationdefinition[GO:1901631]  
1
  • IDAAlzheimers_University_of_Toronto
Protein importdefinition[GO:0017038]  
1
  • IDAAlzheimers_University_of_Toronto
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IDABHF-UCL
Regulation of axon extensiondefinition[GO:0030516]  
1
  • TASUniProtKB
Regulation of beta-amyloid clearancedefinition[GO:1900221]  
1
  • IDAAlzheimers_University_of_Toronto
Regulation of Cdc42 protein signal transductiondefinition[GO:0032489]  
1
  • IDABHF-UCL
Regulation of neuron deathdefinition[GO:1901214]  
1
  • IDAAlzheimers_University_of_Toronto
Regulation of neuronal synaptic plasticitydefinition[GO:0048168]  
1
  • TASUniProtKB
Regulation of tau-protein kinase activitydefinition[GO:1902947]  
1
  • IDAAlzheimers_University_of_Toronto
Response to dietary excessdefinition[GO:0002021] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to reactive oxygen speciesdefinition[GO:0000302]  
1
  • NASUniProtKB
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • IDABHF-UCL
Synaptic transmission, cholinergicdefinition[GO:0007271]  
1
  • TASUniProtKB
Triglyceride metabolic processdefinition[GO:0006641]  
2
  • IDABHF-UCL
Vasodilationdefinition[GO:0042311] silver  
  • IEAOrtholog Compara
Very-low-density lipoprotein particle clearancedefinition[GO:0034447]  
2
  • IMPBHF-UCL
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
2
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Alzheimer's disease  hsa05010+348  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
HDL-mediated lipid transport  REACT_13621  
Retinoid metabolism and transport  REACT_24968  
Scavenging by Class A Receptors  REACT_163699  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_E
GenomeRNAi: 348
PRO: PR:P02649