APOA2 - Apolipoprotein A-II - human protein (Function)
 
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APOA2 »  Apolipoprotein A-II  (Apo-AII)
 
Protein also known as:  Apolipoprotein A2. Cleaved into:  Proapolipoprotein A-II; Truncated apolipoprotein A-II.
Gene name:  APOA2
Family name: Apolipoprotein A2
Entry whose protein(s) existence is based on evidence at protein level
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1 96 1
GENE REF ISO

Function

 show evidences
Overview 
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.  
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein receptor bindingdefinition[GO:0034190]  
1
  • IPIBHF-UCL
Cholesterol bindingdefinition[GO:0015485]  
1
  • IDABHF-UCL
Contributes to cholesterol transporter activitydefinition[GO:0017127]  
1
  • IDABHF-UCL
High-density lipoprotein particle bindingdefinition[GO:0008035] silver  
  • IEAOrtholog Compara
High-density lipoprotein particle receptor bindingdefinition[GO:0070653]  
1
  • IPIBHF-UCL
Lipase inhibitor activitydefinition[GO:0055102]  
1
  • IDABHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • IDABHF-UCL
Lipid transporter activitydefinition[GO:0005319]  
1
  • IDABHF-UCL
Phosphatidylcholine bindingdefinition[GO:0031210]  
1
  • IDABHF-UCL
Phosphatidylcholine-sterol O-acyltransferase activator activitydefinition[GO:0060228]  
1
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
GO biological process 
Acute inflammatory responsedefinition[GO:0002526] silver  
  • IEAOrtholog Compara
Cholesterol effluxdefinition[GO:0033344]  
1
  • IDABHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IDABHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Diacylglycerol catabolic processdefinition[GO:0046340]  
1
  • IDABHF-UCL
High-density lipoprotein particle assemblydefinition[GO:0034380]  
1
  • IDABHF-UCL
High-density lipoprotein particle clearancedefinition[GO:0034384]  
1
  • IDABHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
2
  • IDABHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • IDABHF-UCL
Negative regulation of cholesterol importdefinition[GO:0060621]  
1
  • IDABHF-UCL
Negative regulation of cholesterol transportdefinition[GO:0032375]  
1
  • IMPBHF-UCL
Negative regulation of cholesterol transporter activitydefinition[GO:0060695]  
1
  • IDABHF-UCL
Negative regulation of cytokine secretion involved in immune responsedefinition[GO:0002740]  
1
  • IDABHF-UCL
Negative regulation of lipase activitydefinition[GO:0060192]  
1
  • IDABHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • IDABHF-UCL
Negative regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010903]  
1
  • IDABHF-UCL
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Peptidyl-methionine modificationdefinition[GO:0018206]  
1
  • IDAUniProtKB
Phosphatidylcholine biosynthetic processdefinition[GO:0006656]  
1
  • IDABHF-UCL
Phospholipid catabolic processdefinition[GO:0009395]  
1
  • IDABHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • IDABHF-UCL
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • IDABHF-UCL
Positive regulation of interleukin-8 biosynthetic processdefinition[GO:0045416]  
1
  • IDAUniProtKB
Positive regulation of lipid catabolic processdefinition[GO:0050996]  
1
  • IDABHF-UCL
Protein foldingdefinition[GO:0006457]  
1
  • IDABHF-UCL
Protein oxidationdefinition[GO:0018158]  
1
  • IDAUniProtKB
Regulation of intestinal cholesterol absorptiondefinition[GO:0030300] silver  
  • IEAOrtholog Compara
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • IDABHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749]  
1
  • IDABHF-UCL
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • IDABHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • TASBHF-UCL
Triglyceride-rich lipoprotein particle remodelingdefinition[GO:0034370]  
1
  • IDABHF-UCL
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
PPAR signaling pathway  hsa03320+336  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
PPARA activates gene expression  REACT_116145  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: APOA2
GenomeRNAi: 336
PRO: PR:P02652