APOC1 - Apolipoprotein C-I - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
APOC1 »  Apolipoprotein C-I  (ApoC-I)
 
Protein also known as:  Apolipoprotein C1. Cleaved into:  Truncated apolipoprotein C-I.
Gene name:  APOC1
Family name: Apolipoprotein C1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 96 1
GENE REF ISO

Function

 show evidences
Overview 
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.  
3
  • UniProtKB
GO molecular function 
Fatty acid bindingdefinition[GO:0005504]  
1
  • BHF-UCL
Lipase inhibitor activitydefinition[GO:0055102]  
2
  • BHF-UCL
Phosphatidylcholine bindingdefinition[GO:0031210]  
1
  • BHF-UCL
Phosphatidylcholine-sterol O-acyltransferase activator activitydefinition[GO:0060228]  
1
  • BHF-UCL
Phospholipase inhibitor activitydefinition[GO:0004859]  
1
  • BHF-UCL
GO biological process 
Cholesterol effluxdefinition[GO:0033344]  
1
  • BHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • BHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • BHF-UCL
Lipid metabolic processdefinition[GO:0006629]  
1
  • PINC
Lipoprotein metabolic processdefinition[GO:0042157] silver  
1
  • InterPro 2 GO
Negative regulation of cholesterol transportdefinition[GO:0032375]  
1
  • BHF-UCL
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
1
  • BHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • BHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • BHF-UCL
Negative regulation of lipoprotein lipase activitydefinition[GO:0051005]  
1
  • BHF-UCL
Negative regulation of phosphatidylcholine catabolic processdefinition[GO:0010900]  
1
  • BHF-UCL
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearancedefinition[GO:0010916]  
1
  • BHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • BHF-UCL
Plasma lipoprotein particle remodelingdefinition[GO:0034369]  
1
  • BHF-UCL
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • GOC
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • BHF-UCL
Regulation of cholesterol transportdefinition[GO:0032374]  
1
  • BHF-UCL
Triglyceride metabolic processdefinition[GO:0006641] silver  
1
  • Ortholog Compara
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • BHF-UCL
Very-low-density lipoprotein particle clearancedefinition[GO:0034447]  
1
  • BHF-UCL
Note 
Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.  
2
  • UniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_C1
GenomeRNAi: 341
PRO: PR:P02654