APOC1 - Apolipoprotein C-I - human protein (Function)
 
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APOC1 »  Apolipoprotein C-I
 
Protein also known as:  Apolipoprotein C1. Cleaved into:  Truncated apolipoprotein C-I.
Gene name:  APOC1
Family name: Apolipoprotein C1
Entry whose protein(s) existence is based on evidence at protein level
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1 91 1
GENE REF ISO

Function

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Overview 
Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification.  
1
  • CuratedUniProtKB
GO molecular function 
Fatty acid bindingdefinition[GO:0005504]  
1
  • IDABHF-UCL
Lipase inhibitor activitydefinition[GO:0055102]  
2
  • IDABHF-UCL
Phosphatidylcholine bindingdefinition[GO:0031210]  
1
  • TASBHF-UCL
Phosphatidylcholine-sterol O-acyltransferase activator activitydefinition[GO:0060228]  
1
  • TASBHF-UCL
Phospholipase inhibitor activitydefinition[GO:0004859]  
1
  • IDABHF-UCL
GO biological process 
Cholesterol effluxdefinition[GO:0033344]  
1
  • IDABHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • IDABHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • TASBHF-UCL
Lipid metabolic processdefinition[GO:0006629]  
1
  • TASPINC
Lipoprotein metabolic processdefinition[GO:0042157] silver  
  • IEAInterPro 2 GO
Negative regulation of cholesterol transportdefinition[GO:0032375]  
1
  • IDABHF-UCL
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
1
  • IDABHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • IDABHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • IDABHF-UCL
Negative regulation of lipoprotein lipase activitydefinition[GO:0051005]  
1
  • IDABHF-UCL
Negative regulation of phosphatidylcholine catabolic processdefinition[GO:0010900]  
1
  • IDABHF-UCL
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • IDABHF-UCL
Negative regulation of very-low-density lipoprotein particle clearancedefinition[GO:0010916]  
1
  • IDABHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • IDABHF-UCL
Plasma lipoprotein particle remodelingdefinition[GO:0034369]  
1
  • IDABHF-UCL
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • TASGOC
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • TASBHF-UCL
Regulation of cholesterol transportdefinition[GO:0032374]  
1
  • ICBHF-UCL
Triglyceride metabolic processdefinition[GO:0006641] silver  
  • IEAOrtholog Compara
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • TASBHF-UCL
Very-low-density lipoprotein particle clearancedefinition[GO:0034447]  
1
  • IGIBHF-UCL
Note 
Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_C1
GenomeRNAi: 341
PRO: PR:P02654