APOC2 - Apolipoprotein C-II - human protein (Function)
 
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APOC2 »  Apolipoprotein C-II  (Apo-CII)
 
Protein also known as:  Apolipoprotein C2. Cleaved into:  Proapolipoprotein C-II.
Gene name:  APOC2
Family name: Apolipoprotein C2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 1
GENE REF ISO

Function

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Overview 
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.  
3
  • UniProtKB
GO molecular function 
Lipase inhibitor activitydefinition[GO:0055102]  
1
  • BHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • BHF-UCL
Lipoprotein lipase activator activitydefinition[GO:0060230]  
2
  • BHF-UCL
  • CACAO
Phospholipase activator activitydefinition[GO:0016004]  
1
  • BHF-UCL
Phospholipase bindingdefinition[GO:0043274]  
1
  • BHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
GO biological process 
Cholesterol effluxdefinition[GO:0033344]  
1
  • BHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • BHF-UCL
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • BHF-UCL
Chylomicron remodelingdefinition[GO:0034371]  
1
  • BHF-UCL
High-density lipoprotein particle clearancedefinition[GO:0034384]  
1
  • BHF-UCL
Lipid catabolic processdefinition[GO:0016042]  
1
  • UniProtKB KW
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • GOC
Negative regulation of cholesterol transportdefinition[GO:0032375]  
1
  • BHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • BHF-UCL
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearancedefinition[GO:0010916]  
1
  • BHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • BHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723]  
1
  • BHF-UCL
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
2
  • BHF-UCL
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • BHF-UCL
Positive regulation of phospholipid catabolic processdefinition[GO:0060697]  
1
  • BHF-UCL
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • BHF-UCL
Positive regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010902]  
1
  • BHF-UCL
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • BHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • BHF-UCL
Triglyceride-rich lipoprotein particle remodelingdefinition[GO:0034370]  
1
  • BHF-UCL
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
1
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
HDL-mediated lipid transport  REACT_13621  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_C2
GenomeRNAi: 344
PRO: PR:P02655