APOC2 - Apolipoprotein C-II - human protein (Function)
 
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APOC2 »  Apolipoprotein C-II
 
Gene name:  APOC2
Family name: Apolipoprotein C2
Entry whose protein(s) existence is based on evidence at protein level
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1 78 1
GENE REF ISO

Function

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Overview 
Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.  
  • CuratedUniProtKB
GO molecular function 
Lipase inhibitor activitydefinition[GO:0055102]  
1
  • IDABHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • IDABHF-UCL
Lipoprotein lipase activator activitydefinition[GO:0060230]  
1
  • IDABHF-UCL
Phospholipase activator activitydefinition[GO:0016004]  
1
  • IDABHF-UCL
Phospholipase bindingdefinition[GO:0043274]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IMPBHF-UCL
GO biological process 
Cholesterol effluxdefinition[GO:0033344]  
1
  • IDABHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • ICBHF-UCL
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • IDABHF-UCL
Chylomicron remodelingdefinition[GO:0034371]  
1
  • ICBHF-UCL
High-density lipoprotein particle clearancedefinition[GO:0034384]  
1
  • IMPBHF-UCL
Lipid catabolic processdefinition[GO:0016042]  
  • IEAUniProtKB KW
Lipoprotein transportdefinition[GO:0042953] silver  
  • IEAOrtholog Compara
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • IDAGOC
Negative regulation of cholesterol transportdefinition[GO:0032375]  
1
  • IMPBHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • IDABHF-UCL
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • IDABHF-UCL
Negative regulation of very-low-density lipoprotein particle clearancedefinition[GO:0010916]  
1
  • IDABHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • IDABHF-UCL
Positive regulation of fatty acid biosynthetic processdefinition[GO:0045723]  
1
  • IDABHF-UCL
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
2
  • IDABHF-UCL
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • IDABHF-UCL
Positive regulation of phospholipid catabolic processdefinition[GO:0060697]  
1
  • IDABHF-UCL
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • IDABHF-UCL
Positive regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010902]  
1
  • ICBHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • ICBHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • IMPBHF-UCL
Triglyceride-rich lipoprotein particle remodelingdefinition[GO:0034370]  
1
  • TASBHF-UCL
Very-low-density lipoprotein particle remodelingdefinition[GO:0034372]  
1
  • TASBHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
HDL-mediated lipid transport  REACT_13621  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_C2
GenomeRNAi: 344
PRO: PR:P02655