APOC3 - Apolipoprotein C-III - human protein (Function)
 
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APOC3 »  Apolipoprotein C-III  (Apo-CIII)
 
Protein also known as:  Apolipoprotein C3.
Gene name:  APOC3
Family name: Apolipoprotein C3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 163 1
GENE REF ISO

Function

 show evidences
Overview 
Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.  
  • CuratedUniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
1
  • ICBHF-UCL
Enzyme regulator activitydefinition[GO:0030234]  
1
  • IDABHF-UCL
High-density lipoprotein particle receptor bindingdefinition[GO:0070653]  
1
  • IPIBHF-UCL
Lipase inhibitor activitydefinition[GO:0055102]  
4
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
2
  • IDABHF-UCL
GO biological process 
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cholesterol effluxdefinition[GO:0033344]  
2
  • IDABHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IMPBHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • IDABHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • IMPBHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Lipoprotein transportdefinition[GO:0042953] silver  
  • IEAOrtholog Compara
Negative regulation of cholesterol importdefinition[GO:0060621]  
1
  • IMPBHF-UCL
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
2
  • IDABHF-UCL
Negative regulation of high-density lipoprotein particle clearancedefinition[GO:0010987]  
1
  • IMPBHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • IDABHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • IDABHF-UCL
Negative regulation of lipoprotein lipase activitydefinition[GO:0051005]  
3
  • IDABHF-UCL
Negative regulation of low-density lipoprotein particle clearancedefinition[GO:0010989]  
1
  • IMPBHF-UCL
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • IDABHF-UCL
Negative regulation of triglyceride catabolic processdefinition[GO:0010897]  
2
  • IDABHF-UCL
Negative regulation of very-low-density lipoprotein particle clearancedefinition[GO:0010916]  
1
  • IDABHF-UCL
Negative regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010903]  
2
  • ICBHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • IDABHF-UCL
Regulation of Cdc42 protein signal transductiondefinition[GO:0032489]  
1
  • IDABHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • ICBHF-UCL
Triglyceride catabolic processdefinition[GO:0019433]  
1
  • IDABHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • IMPBHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • IMPHGNC
Triglyceride mobilizationdefinition[GO:0006642] silver  
  • IEAOrtholog Compara
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • TASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
PPAR signaling pathway  hsa03320+345  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
HDL-mediated lipid transport  REACT_13621  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_C3
GenomeRNAi: 345
PRO: PR:P02656