APOC3 - Apolipoprotein C-III - human protein (Function)
 
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APOC3 »  Apolipoprotein C-III  (Apo-CIII)
 
Protein also known as:  Apolipoprotein C3.
Gene name:  APOC3
Family name: Apolipoprotein C3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 168 1
GENE REF ISO

Function

 show evidences
Overview 
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.  
3
  • UniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
1
  • BHF-UCL
Enzyme regulator activitydefinition[GO:0030234]  
1
  • BHF-UCL
High-density lipoprotein particle receptor bindingdefinition[GO:0070653]  
1
  • BHF-UCL
Lipase inhibitor activitydefinition[GO:0055102]  
4
  • BHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
2
  • BHF-UCL
GO biological process 
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Cholesterol effluxdefinition[GO:0033344]  
2
  • BHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • BHF-UCL
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Chylomicron remnant clearancedefinition[GO:0034382]  
1
  • BHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • BHF-UCL
High-density lipoprotein particle remodelingdefinition[GO:0034375]  
1
  • BHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Lipoprotein transportdefinition[GO:0042953] silver  
1
  • Ortholog Compara
Negative regulation of cholesterol importdefinition[GO:0060621]  
1
  • BHF-UCL
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
2
  • BHF-UCL
Negative regulation of high-density lipoprotein particle clearancedefinition[GO:0010987]  
1
  • BHF-UCL
Negative regulation of lipid catabolic processdefinition[GO:0050995]  
1
  • BHF-UCL
Negative regulation of lipid metabolic processdefinition[GO:0045833]  
1
  • BHF-UCL
Negative regulation of lipoprotein lipase activitydefinition[GO:0051005]  
3
  • BHF-UCL
Negative regulation of low-density lipoprotein particle clearancedefinition[GO:0010989]  
1
  • BHF-UCL
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • BHF-UCL
Negative regulation of triglyceride catabolic processdefinition[GO:0010897]  
2
  • BHF-UCL
Negative regulation of very-low-density lipoprotein particle clearancedefinition[GO:0010916]  
1
  • BHF-UCL
Negative regulation of very-low-density lipoprotein particle remodelingdefinition[GO:0010903]  
2
  • BHF-UCL
Phospholipid effluxdefinition[GO:0033700]  
1
  • BHF-UCL
Regulation of Cdc42 protein signal transductiondefinition[GO:0032489]  
1
  • BHF-UCL
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Reverse cholesterol transportdefinition[GO:0043691]  
1
  • BHF-UCL
Triglyceride catabolic processdefinition[GO:0019433]  
1
  • BHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • BHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • HGNC
Triglyceride mobilizationdefinition[GO:0006642] silver  
1
  • Ortholog Compara
Very-low-density lipoprotein particle assemblydefinition[GO:0034379]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
PPAR signaling pathway  hsa03320+345  
According to Reactome, this protein belongs to the following pathways:
Chylomicron-mediated lipid transport  REACT_6841  
HDL-mediated lipid transport  REACT_13621  
Retinoid metabolism and transport  REACT_24968  
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_C3
GenomeRNAi: 345
PRO: PR:P02656