FGA - Fibrinogen alpha chain - human protein (Function)
 
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FGA »  Fibrinogen alpha chain
 
Cleaved into:  Fibrinogen alpha chain; Fibrinopeptide A.
Gene name:  FGA
Entry whose protein(s) existence is based on evidence at protein level
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1 258 2
GENE REF ISO

Function

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Overview 
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.  
2
  • UniProtKB
GO molecular function 
Contributes to cell adhesion molecule bindingdefinition[GO:0050839]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • BHF-UCL
  • UniProtKB
Protein binding, bridgingdefinition[GO:0030674] silver  
1
  • InterPro 2 GO
Contributes to receptor bindingdefinition[GO:0005102]  
1
  • BHF-UCL
Structural molecule activitydefinition[GO:0005198]  
2
  • BHF-UCL
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
1
  • Ortholog Compara
Adaptive immune responsedefinition[GO:0002250]  
1
  • UniProtKB KW
Blood coagulation, common pathwaydefinition[GO:0072377]  
2
  • BHF-UCL
Blood coagulation, fibrin clot formationdefinition[GO:0072378]  
1
  • UniProtKB
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • BHF-UCL
Cellular protein complex assemblydefinition[GO:0043623]  
1
  • BHF-UCL
Cellular response to granulocyte colony-stimulating factordefinition[GO:1990643] silver  
1
  • Ortholog Compara
Cellular response to interleukin-6definition[GO:0071354] silver  
1
  • Ortholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
1
  • Ortholog Compara
Fibrinolysisdefinition[GO:0042730]  
1
  • UniProtKB
Induction of bacterial agglutinationdefinition[GO:0043152] silver  
1
  • CACAO
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Liver regenerationdefinition[GO:0097421] silver  
1
  • Ortholog Compara
Negative regulation of blood coagulation, common pathwaydefinition[GO:2000261]  
1
  • BHF-UCL
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902042]  
1
  • BHF-UCL
Plasminogen activationdefinition[GO:0031639]  
1
  • UniProtKB
Platelet aggregationdefinition[GO:0070527]  
2
  • UniProtKB
  • BHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • BHF-UCL
Positive regulation of exocytosisdefinition[GO:0045921]  
1
  • BHF-UCL
Positive regulation of heterotypic cell-cell adhesiondefinition[GO:0034116]  
1
  • BHF-UCL
Positive regulation of peptide hormone secretiondefinition[GO:0090277]  
1
  • BHF-UCL
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • BHF-UCL
Positive regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900026]  
1
  • BHF-UCL
Positive regulation of vasoconstrictiondefinition[GO:0045907]  
1
  • BHF-UCL
Protein complex assemblydefinition[GO:0006461]  
1
  • UniProtKB
Protein polymerizationdefinition[GO:0051258]  
1
  • BHF-UCL
Response to calcium iondefinition[GO:0051592]  
1
  • BHF-UCL
Response to cycloheximidedefinition[GO:0046898] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to genisteindefinition[GO:0033595] silver  
1
  • Ortholog Compara
Response to morphinedefinition[GO:0043278] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2243  
According to Reactome, this protein belongs to the following pathways:
Amyloids  R-HSA-977225  
Common Pathway of Fibrin Clot Formation  R-HSA-140875  
GRB2:SOS provides linkage to MAPK signaling for Integrins  R-HSA-354194  
Integrin alphaIIb beta3 signaling  R-HSA-354192  
Integrin cell surface interactions  R-HSA-216083  
MAP2K and MAPK activation  R-HSA-5674135  
p130Cas linkage to MAPK signaling for integrins  R-HSA-372708  
Platelet degranulation  R-HSA-114608  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fibrinogen_alpha_chain
GenomeRNAi: 2243
PRO: PR:P02671