FGA - Fibrinogen alpha chain - human protein (Function)
 
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Protein
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FGA »  Fibrinogen alpha chain
 
Cleaved into:  Fibrinogen alpha chain; Fibrinopeptide A.
Gene name:  FGA
Entry whose protein(s) existence is based on evidence at protein level
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1 198 2
GENE REF ISO

Function

 show evidences
Overview 
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein binding, bridgingdefinition[GO:0030674] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102] silver  
  • IEAInterPro 2 GO
GO biological process 
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
Response to calcium iondefinition[GO:0051592]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2243  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fibrinogen_alpha_chain
GenomeRNAi: 2243
PRO: PR:P02671