FGB - Fibrinogen beta chain - human protein (Function)
 
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FGB »  Fibrinogen beta chain
 
Cleaved into:  Fibrinogen beta chain; Fibrinopeptide B.
Gene name:  FGB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.  
  • CuratedUniProtKB
GO molecular function 
Chaperone bindingdefinition[GO:0051087]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein binding, bridgingdefinition[GO:0030674] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to interleukin-1definition[GO:0071347] silver  
  • IEAOrtholog Compara
Cellular response to leptin stimulusdefinition[GO:0044320] silver  
  • IEAOrtholog Compara
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
Response to calcium iondefinition[GO:0051592]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2244  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fibrinogen_beta_chain
GenomeRNAi: 2244
PRO: PR:P02675