FGB - Fibrinogen beta chain - human protein (Medical)
 
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FGB »  Fibrinogen beta chain
 
Cleaved into:  Fibrinogen beta chain; Fibrinopeptide B.
Gene name:  FGB
Entry whose protein(s) existence is based on evidence at protein level
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1 203 1
GENE REF ISO

Displayed isoform: Iso 1

 
 

Medical

 show evidences
Disease 
Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.  
  • CuratedUniProtKB
According to Orphanet, this protein is involved in the following diseases:
Familial afibrinogenemia  98880  
Familial dysfibrinogenemia  98881  
Familial hypodysfibrinogenemia  248408  
Familial hypofibrinogenemia  101041  
Pharmaceutical 
According to DrugBank, this protein binds/interacts with the following drug:
Sucralfate  DB00364  
 

Keywords

Disease 
Disease mutation  definition   [KW-0225]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Organism-specific databases
CTD: 2244
MIM: 202400
PharmGKB: PA163
Polymorphism databases
DMDM: 399492
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.