FGG - Fibrinogen gamma chain - human protein (Function)
 
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FGG »  Fibrinogen gamma chain
 
Gene name:  FGG
Entry whose protein(s) existence is based on evidence at protein level
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1 199 2
GENE REF ISO

Function

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Overview 
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.  
  • CuratedUniProtKB
GO molecular function 
Cell adhesion molecule bindingdefinition[GO:0050839]  
1
  • IPIBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein binding, bridgingdefinition[GO:0030674] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • IPIBHF-UCL
Structural molecule activitydefinition[GO:0005198]  
1
  • IDABHF-UCL
GO biological process 
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • IDABHF-UCL
Cellular protein complex assemblydefinition[GO:0043623]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • IDABHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902042]  
1
  • IDABHF-UCL
Platelet aggregationdefinition[GO:0070527]  
1
  • IDABHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • IDABHF-UCL
Positive regulation of exocytosisdefinition[GO:0045921]  
1
  • IDABHF-UCL
Positive regulation of heterotypic cell-cell adhesiondefinition[GO:0034116]  
1
  • IDABHF-UCL
Positive regulation of peptide hormone secretiondefinition[GO:0090277]  
1
  • IDABHF-UCL
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • IDABHF-UCL
Positive regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900026]  
1
  • NASBHF-UCL
Positive regulation of vasoconstrictiondefinition[GO:0045907]  
1
  • IDABHF-UCL
Protein polymerizationdefinition[GO:0051258]  
1
  • IMPBHF-UCL
Response to calcium iondefinition[GO:0051592]  
1
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+2266  
Staphylococcus aureus infection  hsa05150+2266  
According to Reactome, this protein belongs to the following pathways:
Common Pathway  REACT_1439  
Integrin alphaIIb beta3 signaling  REACT_15523  
Integrin cell surface interactions  REACT_13552  
p130Cas linkage to MAPK signaling for integrins  REACT_15381  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FGG
GenomeRNAi: 2266
PRO: PR:P02679