CHRNA1 - Acetylcholine receptor subunit alpha - human protein (Function)
 
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Protein
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CHRNA1 »  Acetylcholine receptor subunit alpha
 
Gene name:  CHRNA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 2
GENE REF ISO

Function

 show evidences
Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.1  
GO molecular function 
Contributes to acetylcholine bindingdefinition[GO:0042166]  
1
  • ISSBHF-UCL
Contributes to acetylcholine receptor activitydefinition[GO:0015464]  
1
  • ISSBHF-UCL
Contributes to acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
2
  • IMPMGI
  • ISSBHF-UCL
Ion channel activitydefinition[GO:0005216]  
1
  • TASPINC
GO biological process 
Cation transportdefinition[GO:0006812]  
3
  • IMPGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Muscle cell cellular homeostasisdefinition[GO:0046716]  
1
  • IMPBHF-UCL
Musculoskeletal movementdefinition[GO:0050881]  
1
  • IMPBHF-UCL
Neuromuscular junction developmentdefinition[GO:0007528]  
1
  • IMPMGI
Neuromuscular processdefinition[GO:0050905]  
1
  • IMPBHF-UCL
Neuromuscular synaptic transmissiondefinition[GO:0007274]  
1
  • IMPMGI
Neuron cellular homeostasisdefinition[GO:0070050]  
1
  • IMPBHF-UCL
Neuronal action potentialdefinition[GO:0019228]  
1
  • IMPBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
2
  • IMPMGI
  • IMPBHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Skeletal muscle contractiondefinition[GO:0003009]  
1
  • IMPBHF-UCL
Skeletal muscle tissue growthdefinition[GO:0048630]  
1
  • IMPBHF-UCL
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1134  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cholinergic_receptor,_nicotinic,_alpha_1
GenomeRNAi: 1134
PRO: PR:P02708
Chemistry
GuidetoPHARMACOLOGY: 462