CHRNA1 - Acetylcholine receptor subunit alpha - human protein (Sequence)
 
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CHRNA1 »  Acetylcholine receptor subunit alpha
 
Gene name:  CHRNA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 47 2
GENE REF ISO

Displayed isoform: Iso 2     

 
 
Isoform Iso 2   482 aaMass: 54546 Da,  pI: 5.78
MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE VTVGLQLIQL INVDEVNQIV TTNVRLKQGD MVDLPRPSCV TLGVPLFSHL QNEQWVDYNL KWNPDDYGGV KKIHIPSEKI WRPDLVLYNN ADGDFAIVKF TKVLLQYTGH ITWTPPAIFK SYCEIIVTHF PFDEQNCSMK LGTWTYDGSV VAINPESDQP DLSNFMESGE WVIKESRGWK HSVTYSCCPD TPYLDITYHF VMQRLPLYFI VNVIIPCLLF SFLTGLVFYL PTDSGEKMTL SISVLLSLTV FLLVIVELIP STSSAVPLIG KYMLFTMVFV IASIIITVIV INTHHRSPST HVMPNWVRKV FIDTIPNIMF FSTMKRPSRE KQDKKIFTED IDISDISGKP GPPPMGFHSP LIKHPEVKSA IEGIKYIAET MKSDQESNNA AAEWKYVAMV MDHILLGVFM LVCIIGTLAV FAGRLIELNQ QG

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Domain 
Signal  definition   [KW-0732]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Technical term 
Direct protein sequencing  definition   [KW-0903]
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 1.20.120.370
Gene3D: 2.70.170.10
InterPro: IPR002394 [ Nicotinic acetylcholine rcpt ]
InterPro: IPR006202 [ Neur chan lig-bd ]
InterPro: IPR006029 [ Neurotrans-gated channel TM ]
InterPro: IPR027361 [ Acetylcholine rcpt TM ]
InterPro: IPR018000 [ Neurotransmitter ion chnl CS ]
InterPro: IPR006201 [ Neur channel ]
PANTHER: PTHR18945 [ PTHR18945 ]
Pfam: PF02931 [ Neur chan LBD ]
Pfam: PF02932 [ Neur chan memb ]
PRINTS: PR00254 [ NICOTINICR ]
PRINTS: PR00252 [ NRIONCHANNEL ]
PROSITE: PS00236 [ NEUROTR ION CHANNEL ]
SUPFAM: SSF63712 [ SSF63712 ]
SUPFAM: SSF90112 [ SSF90112 ]
Genome annotation databases
Ensembl: Transcript: ENST00000261007;  Protein: ENSP00000261007;  Gene: ENSG00000138435.
Ensembl: Transcript: ENST00000348749;  Protein: ENSP00000261008;  Gene: ENSG00000138435.
Ensembl: Transcript: ENST00000435083;  Protein: ENSP00000395805;  Gene: ENSG00000138435.
Ensembl: Transcript: ENST00000409219;  Protein: ENSP00000386611;  Gene: ENSG00000138435.
Ensembl: Transcript: ENST00000409323;  Protein: ENSP00000386684;  Gene: ENSG00000138435.
Ensembl: Transcript: ENST00000409542;  Protein: ENSP00000387026;  Gene: ENSG00000138435.
KEGG: hsa:1134
UCSC: uc002ujd.2
Organism-specific databases
MGI: MGI:87885 [ Chrna1 ]
PTM databases
PhosphoSite: P02708
Phylogenomic databases
eggNOG: NOG314424
HOGENOM: HOG000006756
HOVERGEN: HBG003756
InParanoid: P02708
KO: K04803
OMA: THVMPNW
OrthoDB: EOG72JWGV
PhylomeDB: P02708
Sequence databases
CCDS: CCDS2261.1 [ P02708-2 ]
CCDS: CCDS33331.1 [ P02708-1 ]
EMBL: Genomic DNA:  X70108 . Translation:  CAA49705.1 . Sequence problems.
EMBL: mRNA:  Y00762 . Translation:  CAA68731.1 .
EMBL: Genomic DNA:  CH471058 . Translation:  EAX11127.1 .
EMBL: Genomic DNA:  CH471058 . Translation:  EAX11125.1 .
EMBL: Genomic DNA:  X17104 . Translation:  CAA34960.1 .
EMBL: mRNA:  AK299445 . Translation:  BAG61418.1 .
EMBL: Genomic DNA:  X02502 , X02503 , X02504 , X02505 , X02506 , X02507 , X02508 . Translation:  CAA26344.1 .
EMBL: mRNA:  S77094 . Translation:  AAD14247.1 .
IPI: IPI00022298
IPI: IPI00218234
PIR: S10148
PIR: A03168
RefSeq: Protein:  NP_001034612.1. Nucleotide sequence:  NM_001039523.2.
RefSeq: Protein:  NP_000070.1. Nucleotide sequence:  NM_000079.3.
UniProtKB: P02708
Protocols and materials databases
DNASU: 1134