SLC4A1 - Band 3 anion transport protein - human protein (Function)
 
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Protein
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SLC4A1 »  Band 3 anion transport protein
 
Protein also known as:  Solute carrier family 4 member 1; CD antigen CD233.
Gene name:  SLC4A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 231 1
GENE REF ISO

Function

 show evidences
Overview 
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the anion exchanger (ae) family  2.A.31.1.1  
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Anion transmembrane transporter activitydefinition[GO:0008509]  
1
  • TASPINC
Anion:anion antiporter activitydefinition[GO:0015301]  
1
  • IDAUniProtKB
Ankyrin bindingdefinition[GO:0030506]  
1
  • IPIBHF-UCL
Bicarbonate transmembrane transporter activitydefinition[GO:0015106]  
1
  • IDAUniProtKB
Chloride transmembrane transporter activitydefinition[GO:0015108]  
  • ISSOrtholog Curator
Inorganic anion exchanger activitydefinition[GO:0005452]  
1
  • IDAUniProtKB
Protein anchordefinition[GO:0043495]  
1
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
GO biological process 
Anion transportdefinition[GO:0006820]  
1
  • IDAUniProtKB
Bicarbonate transportdefinition[GO:0015701]  
1
  • IDAUniProtKB
Cellular ion homeostasisdefinition[GO:0006873]  
1
  • TASPINC
Chloride transmembrane transportdefinition[GO:1902476]  
  • ISSOrtholog Curator
  • IEAOrtholog Compara
Chloride transportdefinition[GO:0006821]  
  • ISSOrtholog Curator
Enzymatic activity 
It is regulated in the following manner
Phenyl isothiocyanate inhibits anion transport in vitro.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Collecting duct acid secretion  hsa04966+6521  
According to Reactome, this protein belongs to the following pathways:
Bicarbonate transporters  REACT_19298  
Erythrocytes take up carbon dioxide and release oxygen  REACT_121329  
Erythrocytes take up oxygen and release carbon dioxide  REACT_121380  
 

Keywords

Biological process 
Anion exchange  definition   [KW-0039]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Band_3
GenomeRNAi: 6521
PRO: PR:P02730