SLC4A1 - Band 3 anion transport protein - human protein (Function)
 
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Protein
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SLC4A1 »  Band 3 anion transport protein
 
Protein also known as:  Solute carrier family 4 member 1; CD antigen CD233.
Gene name:  SLC4A1
Entry whose protein(s) existence is based on evidence at protein level
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1 215 1
GENE REF ISO

Function

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Overview 
Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the anion exchanger (ae) family  2.A.31.1.1  
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Anion transmembrane transporter activitydefinition[GO:0008509]  
1
  • TASPINC
Anion:anion antiporter activitydefinition[GO:0015301]  
1
  • IDAUniProtKB
Ankyrin bindingdefinition[GO:0030506]  
1
  • IPIBHF-UCL
Chloride transmembrane transporter activitydefinition[GO:0015108]  
  • ISSOrtholog Curator
Protein anchordefinition[GO:0043495]  
1
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
GO biological process 
Anion transportdefinition[GO:0006820]  
1
  • IDAUniProtKB
Cellular ion homeostasisdefinition[GO:0006873]  
1
  • TASPINC
Chloride transmembrane transportdefinition[GO:1902476]  
  • ISSOrtholog Curator
Chloride transportdefinition[GO:0006821]  
  • ISSOrtholog Curator
Ion transmembrane transportdefinition[GO:0034220]  
3
  • IDAGOC
  • ISSOrtholog Curator
Enzymatic activity 
It is regulated in the following manner
Phenyl isothiocyanate inhibits anion transport in vitro.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Collecting duct acid secretion  hsa04966+6521  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Anion exchange  definition   [KW-0039]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Band_3
GenomeRNAi: 6521
PRO: PR:P02730