CRP - C-reactive protein - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CRP »  C-reactive protein
 
Cleaved into:  C-reactive protein(1-205).
Gene name:  CRP
Family name: Pentaxin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 1090 2
GENE REF ISO

Function

 show evidences
Overview 
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.  
  • CuratedUniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485] silver  
  • IEAOrtholog Compara
Choline bindingdefinition[GO:0033265]  
1
  • TASBHF-UCL
Low-density lipoprotein particle bindingdefinition[GO:0030169]  
1
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • TASBHF-UCL
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular response to calcium iondefinition[GO:0071277] silver  
  • IEAOrtholog Compara
Complement activation, classical pathwaydefinition[GO:0006958] silver  
  • IEAOrtholog Compara
Defense response to Gram-positive bacteriumdefinition[GO:0050830]  
1
  • TASBHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Negative regulation of lipid storagedefinition[GO:0010888]  
1
  • IDABHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • IDABHF-UCL
Opsonizationdefinition[GO:0008228]  
1
  • TASBHF-UCL
Positive regulation of dendrite developmentdefinition[GO:1900006] silver  
  • IEAOrtholog Compara
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to lead iondefinition[GO:0010288] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 2 calcium ions per subunit.  
  • CuratedUniProtKB
Note 
This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: C-reactive_protein
GenomeRNAi: 1401
PRO: PR:P02741