APCS - Serum amyloid P-component - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
APCS »  Serum amyloid P-component  (SAP)
 
Protein also known as:  9.5S alpha-1-glycoprotein. Cleaved into:  Serum amyloid P-component(1-203).
Gene name:  APCS
Family name: Pentaxin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 73 1
GENE REF ISO

Function

 show evidences
Overview 
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the pentraxin (pentraxin) family  1.C.92.1.2  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDABHF-UCL
Complement component C1q bindingdefinition[GO:0001849]  
1
  • IDABHF-UCL
Unfolded protein bindingdefinition[GO:0051082]  
1
  • TASPINC
Virion bindingdefinition[GO:0046790]  
1
  • IDABHF-UCL
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • TASPINC
Chaperone-mediated protein complex assemblydefinition[GO:0051131]  
1
  • TASPINC
Innate immune responsedefinition[GO:0045087]  
1
  • IDABHF-UCL
Negative regulation of acute inflammatory responsedefinition[GO:0002674]  
1
  • ICBHF-UCL
Negative regulation of exo-alpha-sialidase activitydefinition[GO:1903016]  
1
  • IDABHF-UCL
Negative regulation of glycoprotein metabolic processdefinition[GO:1903019]  
1
  • IDABHF-UCL
Negative regulation of monocyte differentiationdefinition[GO:0045656]  
1
  • IDABHF-UCL
Negative regulation of viral entry into host celldefinition[GO:0046597]  
1
  • IDABHF-UCL
Negative regulation of viral processdefinition[GO:0048525]  
1
  • IDABHF-UCL
Negative regulation of wound healingdefinition[GO:0061045]  
1
  • ICBHF-UCL
Protein foldingdefinition[GO:0006457]  
1
  • TASPINC
Enzymatic activity 
It requires the following cofactor
Binds 2 calcium ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Amyloids  REACT_75925  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Serum_amyloid_P_component
GenomeRNAi: 325
PRO: PR:P02743