C1QA - Complement C1q subcomponent subunit A - human protein (Function)
 
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Protein
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References

 
C1QA »  Complement C1q subcomponent subunit A
 
Gene name:  C1QA
Entry whose protein(s) existence is based on evidence at protein level
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1 60 1
GENE REF ISO

Function

 show evidences
Overview 
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+712  
Complement and coagulation cascades  hsa04610+712  
Pertussis  hsa05133+712  
Prion diseases  hsa05020+712  
Staphylococcus aureus infection  hsa05150+712  
Systemic lupus erythematosus  hsa05322+712  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: C1QA
GenomeRNAi: 712
PRO: PR:P02745