APOH - Beta-2-glycoprotein 1 - human protein (Function)
 
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APOH »  Beta-2-glycoprotein 1
 
Protein also known as:  Activated protein C-binding protein.
Gene name:  APOH
Entry whose protein(s) existence is based on evidence at protein level
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1 172 1
GENE REF ISO

Function

 show evidences
Overview 
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.  
  • CuratedUniProtKB
GO molecular function 
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIBHF-UCL
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Lipid bindingdefinition[GO:0008289]  
1
  • IDABHF-UCL
Lipoprotein lipase activator activitydefinition[GO:0060230]  
1
  • IDABHF-UCL
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIBHF-UCL
  • IPIIntAct
GO biological process 
Blood coagulation, intrinsic pathwaydefinition[GO:0007597]  
1
  • IDABHF-UCL
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IDABHF-UCL
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell migrationdefinition[GO:0010596]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • IDABHF-UCL
Negative regulation of fibrinolysisdefinition[GO:0051918]  
1
  • IDABHF-UCL
Negative regulation of myeloid cell apoptotic processdefinition[GO:0033033]  
1
  • IDABHF-UCL
Negative regulation of smooth muscle cell apoptotic processdefinition[GO:0034392]  
1
  • IDABHF-UCL
Plasminogen activationdefinition[GO:0031639]  
1
  • IDABHF-UCL
Positive regulation of blood coagulationdefinition[GO:0030194]  
1
  • TASBHF-UCL
Positive regulation of lipoprotein lipase activitydefinition[GO:0051006]  
1
  • IDABHF-UCL
Regulation of fibrinolysisdefinition[GO:0051917]  
1
  • IDABHF-UCL
Triglyceride metabolic processdefinition[GO:0006641]  
1
  • IDABHF-UCL
Triglyceride transportdefinition[GO:0034197]  
1
  • ISSBHF-UCL
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Apolipoprotein_H
GenomeRNAi: 350
PRO: PR:P02749