FN1 - Fibronectin - human protein (Function)
 
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FN1 »  Fibronectin  (FN)
 
Protein also known as:  Cold-insoluble globulin (CIG). Cleaved into:  Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3.
Gene name:  FN1
Entry whose protein(s) existence is based on evidence at protein level
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1 158 17
GENE REF ISO

Function

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Overview 
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.  
1
  • UniProtKB
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.  
1
  • UniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • UniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB
Integrin bindingdefinition[GO:0005178]  
2
  • UniProtKB
Peptidase activator activitydefinition[GO:0016504] silver  
1
  • Ortholog Compara
Protease bindingdefinition[GO:0002020]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
22
  • IntAct
  • MTBbase
  • UniProtKB
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • UniProtKB KW
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
Calcium-independent cell-matrix adhesiondefinition[GO:0007161] silver  
1
  • Ortholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB
Cell-substrate junction assemblydefinition[GO:0007044] silver  
1
  • Ortholog Compara
Endodermal cell differentiationdefinition[GO:0035987]  
1
  • UniProtKB
Integrin activationdefinition[GO:0033622]  
1
  • UniProtKB
Peptide cross-linkingdefinition[GO:0018149]  
1
  • BHF-UCL
Positive regulation of axon extensiondefinition[GO:0045773] silver  
1
  • Ortholog Compara
Positive regulation of peptidase activitydefinition[GO:0010952] silver  
1
  • Ortholog Compara
Regulation of cell shapedefinition[GO:0008360]  
1
  • UniProtKB KW
Response to woundingdefinition[GO:0009611]  
1
  • UniProtKB
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
2
  • UniProtKB
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+2335  
Bacterial invasion of epithelial cells  hsa05100+2335  
ECM-receptor interaction  hsa04512+2335  
Focal adhesion  hsa04510+2335  
Pathways in cancer  hsa05200+2335  
Regulation of actin cytoskeleton  hsa04810+2335  
Small cell lung cancer  hsa05222+2335  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Degradation of the extracellular matrix  REACT_118572  
ECM proteoglycans  REACT_163906  
Extracellular matrix organization  REACT_118779  
Fibronectin matrix formation  REACT_160131  
GRB2:SOS provides linkage to MAPK signaling for Integrins  REACT_15443  
Integrin alphaIIb beta3 signaling  REACT_15523  
Integrin cell surface interactions  REACT_13552  
Molecules associated with elastic fibres  REACT_150331  
Non-integrin membrane-ECM interactions  REACT_163874  
p130Cas linkage to MAPK signaling for integrins  REACT_15381  
Platelet degranulation  REACT_318  
Syndecan interactions  REACT_163942  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Cell shape  definition   [KW-0133]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fibronectin
GenomeRNAi: 2335
PRO: PR:P02751