FN1 - Fibronectin - human protein (Function)
 
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FN1 »  Fibronectin  (FN)
 
Protein also known as:  Cold-insoluble globulin (CIG). Cleaved into:  Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3.
Gene name:  FN1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.  
4
  • CuratedUniProtKB
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.  
4
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • NASUniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • NASUniProtKB
Peptidase activator activitydefinition[GO:0016504] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
17
  • IPIIntAct
  • IPIMTBbase
  • IPIUniProtKB
  • IPIBHF-UCL
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
  • IEAUniProtKB KW
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Calcium-independent cell-matrix adhesiondefinition[GO:0007161] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • NASUniProtKB
Cell-substrate junction assemblydefinition[GO:0007044] silver  
  • IEAOrtholog Compara
Peptide cross-linkingdefinition[GO:0018149]  
1
  • IDABHF-UCL
Regulation of cell shapedefinition[GO:0008360]  
  • IEAUniProtKB KW
Response to woundingdefinition[GO:0009611]  
1
  • NASUniProtKB
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+2335  
Bacterial invasion of epithelial cells  hsa05100+2335  
ECM-receptor interaction  hsa04512+2335  
Focal adhesion  hsa04510+2335  
Pathways in cancer  hsa05200+2335  
Regulation of actin cytoskeleton  hsa04810+2335  
Small cell lung cancer  hsa05222+2335  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Acute phase  definition   [KW-0011]
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Cell shape  definition   [KW-0133]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Fibronectin
GenomeRNAi: 2335
PRO: PR:P02751