AMBP - Protein AMBP - human protein (Function)
 
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AMBP »  Protein AMBP
 
Cleaved into:  Alpha-1-microglobulin; Inter-alpha-trypsin inhibitor light chain; Trypstatin.
Gene name:  AMBP
Family name: In the N-terminal section Calycin » Lipocalin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.  
1
  • CuratedUniProtKB
Trypstatin is a trypsin inhibitor (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Calcium channel inhibitor activitydefinition[GO:0019855]  
1
  • NASUniProtKB
Calcium oxalate bindingdefinition[GO:0046904]  
1
  • NASUniProtKB
Heme bindingdefinition[GO:0020037]  
1
  • IDAUniProtKB
IgA bindingdefinition[GO:0019862]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • TASUniProtKB
Small molecule bindingdefinition[GO:0036094] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • NASUniProtKB
Female pregnancydefinition[GO:0007565]  
1
  • NASUniProtKB
Heme catabolic processdefinition[GO:0042167]  
1
  • NASUniProtKB
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • TASGOC
Negative regulation of immune responsedefinition[GO:0050777]  
1
  • NASUniProtKB
Negative regulation of JNK cascadedefinition[GO:0046329]  
1
  • TASUniProtKB
Protein catabolic processdefinition[GO:0030163] silver  
  • IEAOrtholog Compara
Protein-chromophore linkagedefinition[GO:0018298]  
  • IEAUniProtKB KW
Regulation of endopeptidase activitydefinition[GO:0052548]  
1
  • TASGOC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Binding and Uptake of Ligands by Scavenger Receptors  REACT_160300  
Note 
In vitro, the first twelve residues of the amino end of the inhibitor appear to have a reactive site capable of inhibiting the activity of a number of enzymes. Its in vivo function is not known.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links