ALB - Serum albumin - human protein (Function)
 
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ALB »  Serum albumin
 
Gene name:  ALB
Family name: ALB/AFP/VDB
Entry whose protein(s) existence is based on evidence at protein level
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1 321 2
GENE REF ISO

Function

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Overview 
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.  
1
  • CuratedUniProtKB
GO molecular function 
Antioxidant activitydefinition[GO:0016209]  
1
  • NASUniProtKB
Chaperone bindingdefinition[GO:0051087]  
1
  • IPIBHF-UCL
Copper ion bindingdefinition[GO:0005507]  
1
  • NASUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144]  
5
  • IDAUniProtKB
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
Fatty acid bindingdefinition[GO:0005504]  
3
  • IDAUniProtKB
Contributes to oxygen bindingdefinition[GO:0019825]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Pyridoxal phosphate bindingdefinition[GO:0030170]  
1
  • IDAUniProtKB
Toxic substance bindingdefinition[GO:0015643]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to starvationdefinition[GO:0009267]  
1
  • IDAUniProtKB
Hemolysis by symbiont of host erythrocytesdefinition[GO:0019836]  
1
  • IDAUniProtKB
Maintenance of mitochondrion locationdefinition[GO:0051659]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of programmed cell deathdefinition[GO:0043069]  
1
  • NASUniProtKB
Positive regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0046010] silver  
  • IEAOrtholog Compara
Response to mercury iondefinition[GO:0046689] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Response to platinum iondefinition[GO:0070541] silver  
  • IEAOrtholog Compara
Retina homeostasisdefinition[GO:0001895]  
1
  • IEPUniProtKB
Transportdefinition[GO:0006810]  
1
  • TASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Binding and Uptake of Ligands by Scavenger Receptors  REACT_160300  
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
Caution 
A peptide arising from positions 166 to 174 was originally (PubMed3087352 and PubMed2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow.  
2
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Serum_albumin
GenomeRNAi: 213
PRO: PR:P02768