PF4 - Platelet factor 4 - human protein (Function)
 
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PF4 »  Platelet factor 4  (PF-4)
 
Protein also known as:  C-X-C motif chemokine 4. Cleaved into:  Platelet factor 4, short form.
Gene name:  PF4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.  
1
  • CuratedUniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
1
  • TASUniProtKB
CXCR3 chemokine receptor bindingdefinition[GO:0048248]  
1
  • IDAUniProtKB
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IDAUniProtKB
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Leukocyte chemotaxisdefinition[GO:0030595]  
1
  • IDAUniProtKB
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IDAUniProtKB
Negative regulation of cytolysisdefinition[GO:0045918]  
1
  • IDABHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • IDABHF-UCL
Negative regulation of megakaryocyte differentiationdefinition[GO:0045653]  
1
  • IDAUniProtKB
Negative regulation of MHC class II biosynthetic processdefinition[GO:0045347]  
1
  • IDABHF-UCL
Platelet activationdefinition[GO:0030168]  
1
  • IDAUniProtKB
Positive regulation of cAMP metabolic processdefinition[GO:0030816]  
1
  • IDAUniProtKB
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • IDAUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IDABHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • IDABHF-UCL
Positive regulation of macrophage differentiationdefinition[GO:0045651]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
1
  • IDABHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+5196  
Cytokine-cytokine receptor interaction  hsa04060+5196  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Chemokine receptors bind chemokines  REACT_15344  
Common Pathway  REACT_1439  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Platelet_factor_4
GenomeRNAi: 5196
PRO: PR:P02776