TF - Serotransferrin - human protein (Function)
 
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Protein
Gene
References

 
TF »  Serotransferrin  (Transferrin)
 
Protein also known as:  Beta-1 metal-binding globulin.
Gene name:  TF
Family name: Transferrin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.  
  • CuratedUniProtKB
GO molecular function 
Ferric iron bindingdefinition[GO:0008199] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+7018  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Iron transport  definition   [KW-0410]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Transferrin
GenomeRNAi: 7018
PRO: PR:P02787