HPX - Hemopexin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
HPX »  Hemopexin
 
Gene name:  HPX
Family name: Hemopexin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 50 1
GENE REF ISO

Function

 show evidences
Overview 
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the membrane attack complex/perforin (macpf) family  1.C.39.8.3  
GO molecular function 
Heme transporter activitydefinition[GO:0015232]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cellular iron ion homeostasisdefinition[GO:0006879]  
1
  • TASPINC
Heme metabolic processdefinition[GO:0042168] silver  
  • IEAOrtholog Compara
Heme transportdefinition[GO:0015886]  
1
  • TASPINC
Hemoglobin metabolic processdefinition[GO:0020027] silver  
  • IEAOrtholog Compara
Positive regulation of humoral immune response mediated by circulating immunoglobulindefinition[GO:0002925] silver  
  • IEAOrtholog Compara
Positive regulation of immunoglobulin productiondefinition[GO:0002639] silver  
  • IEAOrtholog Compara
Positive regulation of interferon-gamma-mediated signaling pathwaydefinition[GO:0060335] silver  
  • IEAOrtholog Compara
Positive regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042511] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Scavenging of heme from plasma  REACT_160163  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Hemopexin
GenomeRNAi: 3263
PRO: PR:P02790