STATH - Statherin - human protein (Function)
 
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Protein
Gene
References

 
STATH »  Statherin
 
Gene name:  STATH
Family name: Histatin/statherin
Entry whose protein(s) existence is based on evidence at protein level
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1 24 2
GENE REF ISO

Function

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Overview 
Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the channel-forming histatin antimicrobial peptide (histatin) family  1.C.79.1.2  
GO molecular function 
Extracellular matrix constituent, lubricant activitydefinition[GO:0030197]  
1
  • NASUniProtKB
Hydroxyapatite bindingdefinition[GO:0046848]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Structural constituent of tooth enameldefinition[GO:0030345]  
1
  • NASUniProtKB
GO biological process 
Biomineral tissue developmentdefinition[GO:0031214]  
  • IEAUniProtKB KW
Negative regulation of bone mineralizationdefinition[GO:0030502]  
1
  • NASUniProtKB
Ossificationdefinition[GO:0001503]  
1
  • TASPINC
Saliva secretiondefinition[GO:0046541]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Salivary secretion  hsa04970+6779  
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STATH
GenomeRNAi: 6779
PRO: PR:P02808