ESR1 - Estrogen receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
ESR1 »  Estrogen receptor  (ER)
 
Protein also known as:  Nuclear receptor subfamily 3 group A member 1.
Gene name:  ESR1
Family name: Nuclear hormone receptor » NR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 1715 4
GENE REF ISO

Function

 show evidences
Overview 
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.  
19
  • UniProtKB
Isoform  Iso 3   Can bind to ERE and inhibit isoform 1.  
20
  • UniProtKB
Isoform  Iso 3   Is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.  
19
  • UniProtKB
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
1
  • MGI
Beta-catenin bindingdefinition[GO:0008013]  
1
  • BHF-UCL
Chromatin bindingdefinition[GO:0003682]  
1
  • UniProtKB
Core promoter sequence-specific DNA bindingdefinition[GO:0001046]  
1
  • UniProtKB
Enzyme bindingdefinition[GO:0019899]  
2
  • UniProtKB
Estrogen receptor activitydefinition[GO:0030284]  
1
  • UniProtKB
Estrogen response element bindingdefinition[GO:0034056]  
2
  • UniProtKB
Estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0038052]  
1
  • MGI
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
Nitric-oxide synthase regulator activitydefinition[GO:0030235]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
64
  • IntAct
  • UniProtKB
  • BHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • BHF-UCL
Steroid bindingdefinition[GO:0005496]  
1
  • Ortholog Curator
Steroid hormone receptor activitydefinition[GO:0003707]  
1
  • PINC
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Androgen metabolic processdefinition[GO:0008209] silver  
1
  • Ortholog Compara
Antral ovarian follicle growthdefinition[GO:0001547] silver  
1
  • Ortholog Compara
Cellular response to estradiol stimulusdefinition[GO:0071392]  
1
  • Ortholog Curator
Chromatin remodelingdefinition[GO:0006338]  
1
  • UniProtKB
Epithelial cell developmentdefinition[GO:0002064] silver  
1
  • Ortholog Compara
Epithelial cell proliferation involved in mammary gland duct elongationdefinition[GO:0060750] silver  
1
  • Ortholog Compara
Intracellular estrogen receptor signaling pathwaydefinition[GO:0030520]  
1
  • UniProtKB
Intracellular steroid hormone receptor signaling pathwaydefinition[GO:0030518]  
1
  • Ortholog Curator
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Mammary gland alveolus developmentdefinition[GO:0060749] silver  
1
  • Ortholog Compara
Mammary gland branching involved in pregnancydefinition[GO:0060745] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
2
  • UniProtKB
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • UniProtKB
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • Ortholog Curator
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • Ortholog Curator
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
1
  • Ortholog Compara
Isoform  Iso 3   Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • UniProtKB
Isoform  Iso 3   Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • UniProtKB
Positive regulation of phospholipase C activitydefinition[GO:0010863]  
1
  • Ortholog Curator
Positive regulation of retinoic acid receptor signaling pathwaydefinition[GO:0048386]  
1
  • BHF-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
2
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • UniProtKB
  • NTNU_SB
  • MGI
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisdefinition[GO:0060527] silver  
1
  • Ortholog Compara
Prostate epithelial cord elongationdefinition[GO:0060523] silver  
1
  • Ortholog Compara
Regulation of apoptotic processdefinition[GO:0042981] silver  
1
  • Ortholog Compara
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Response to estradioldefinition[GO:0032355]  
1
  • BHF-UCL
Response to estrogendefinition[GO:0043627]