MT-ND2 - NADH-ubiquinone oxidoreductase chain 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MT-ND2 »  NADH-ubiquinone oxidoreductase chain 2   [ EC 1.6.5.3 ]
 
Protein also known as:  NADH dehydrogenase subunit 2.
Gene name:  MT-ND2
Family name: Complex I subunit 2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 1
GENE REF ISO

Function

 show evidences
Overview 
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).  
  • CuratedUniProtKB
GO molecular function 
NADH dehydrogenase (ubiquinone) activitydefinition[GO:0008137]  
2
  • NASUniProtKB
GO biological process 
Mitochondrial electron transport, NADH to ubiquinonedefinition[GO:0006120]  
2
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.6.5.3: NADH + ubiquinone + 5 H(+)(In) NAD(+) + ubiquinol + 4 H(+)(Out).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+4536  
Oxidative phosphorylation  hsa00190+4536  
Parkinson's disease  hsa05012+4536  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Respiratory chain  definition   [KW-0679]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MT-ND2
GenomeRNAi: 4536
PRO: PR:P03891